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| 22.09.2021 | 18:00 | Apollon Limassol | - | Olympiada Lympion | 3:1 | |
| 18:00 | APOEL Nikosia | - | Nea Salamina | 2:0 | ||
| 18:00 | Omonia 29is Maiou | - | Paphos FC | 0:1 | ||
| 18:00 | Alki Oroklini | - | AEK Larnaca | 0:4 | ||
| 29.09.2021 | 17:00 | Doxa Katokopias | - | Akritas Chlorakas | 5:1 | |
| 17:00 | Achyronas Liopetri | - | Ethnikos Achna | 0:4 | ||
| 17:00 | Aris Limassol | - | Enosis Neon Paralimni | 2:4 tab |
