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| H (Match allé) | Nacional Potosí | - | Blooming | 3:1 (2:1) | ||
| R (match retour) | Blooming | - | Nacional Potosí | 5:3 (1:0, 2:0, 2:0) tab | ||
| H (Match allé): 28.05.2022 21:00 | R (match retour): 03.06.2022 02:00 | vainqueur: Blooming | ||||
| H (Match allé) | Always Ready | - | Atlético Palmaflor | 2:1 (1:0) | ||
| R (match retour) | Atlético Palmaflor | - | Always Ready | 5:4 (0:0, 2:1, 2:1) tab | ||
| H (Match allé): 29.05.2022 21:00 | R (match retour): 01.06.2022 22:00 | vainqueur: Atlético Palmaflor | ||||
| H (Match allé) | Royal Pari | - | The Strongest | 0:3 (0:1) | ||
| R (match retour) | The Strongest | - | Royal Pari | 4:0 (1:0) | ||
| H (Match allé): 30.05.2022 00:00 | R (match retour): 02.06.2022 02:30 | vainqueur: The Strongest | ||||
| H (Match allé) | Oriente Petrolero | - | Bolívar | 1:0 (1:0) | ||
| R (match retour) | Bolívar | - | Oriente Petrolero | 7:6 (0:0, 1:0, 1:0) tab | ||
| H (Match allé): 30.05.2022 01:30 | R (match retour): 03.06.2022 02:00 | vainqueur: Bolívar | ||||
