Ecuadoran international Leonardo Campana scored a hat-trick as struggling Inter Miami bagged their first win of the Major League Soccer season on Saturday with a 3-2 victory over New England Revolution.

David Beckham's MLS franchise has endured a miserable start to the campaign, taking just one point from five winless games prior to Saturday's home fixture against the Revs to leave themselves bottom of the Eastern Conference.

Another torrid afternoon for Miami manager Phil Neville looked a distinct possibility on Saturday after New England took the lead through a Justin Rennicks goal after 11 minutes.

But Miami hit back with a well-worked move that ended with Campana heading home the equalizer in the 17th minute.

Campana then fired Miami into the lead in the 23rd minute with a spectacular strike, crashing a shot into the roof of the net with a first-time strike from Brazilian midfielder Gregore's low cross.

It looked as if Carles Gil had earned a share of the points for New England when he stepped up to slot a 67th-minute penalty, but Campana completed his hat-trick after prodding home from close range two minutes from time after a blunder by Revs goalkeeper Brad Knighton.

"It's the first win of the season, we shouldn't get carried away, we shouldn't be going out on the town tonight," Miami coach Neville said afterwards.

"We should be focusing on the next game against Seattle. We've got a hell of a lot of work to do, and what I think you saw today was a reflection of what we're trying to build. Eighteen players in our match-day squad who were all just fighting for each other."

Neville, meanwhile, could not hide his joy at the whistle, hugging his staff and players after a dramatic win.

"I was happy at the end for them because they're my guys, they're my boys," Neville said. "I believe in them and I've never stopped believing in them. Today was just a little glimpse of what we can do."

In other games on Saturday, Los Angeles Galaxy defeated Los Angeles FC 2-1 in another stormy installment of the Californian derby known as "El Trafico."

Galaxy took the lead in the 13th minute when Mexican star Javier "Chicharito" Hernandez headed home at the back post from a cross.

More slack defending allowed Sega Coulibaly to make it 2-0 just after the half-hour mark, the Mali-born defender afforded time and space to rifle home a low finish.

Cristian Arango pulled a goal back for LAFC in the 79th minute, and the visitors laid siege to the Galaxy goal for the final stages of the game.

It looked as if LAFC had grabbed a dramatic equalizer when Latif Blessing scrambled home from close range in the eighth minute of added time.

But there was one final twist as the goal was disallowed after intervention from VAR as Galaxy claimed all three points.