| 1. Journée | 18.10.2020 | River Plate | - | 12 de Octubre de Itauguá | 1:2 | ||||
| 2. Journée | 24.10.2020 | Sportivo Luqueño | - | River Plate | 2:0 | ||||
| 3. Journée | 01.11.2020 | River Plate | - | Guaraní | 1:0 | ||||
| 4. Journée | 08.11.2020 | Libertad | - | River Plate | 3:1 | ||||
| 5. Journée | 11.11.2020 | River Plate | - | Guaireña FC | 1:2 |  |
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| 6. Journée | 15.11.2020 | Sol de América | - | River Plate | 2:3 | ||||
| 7. Journée | 20.11.2020 | River Plate | - | Cerro Porteño | 1:2 | |
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| 8. Journée | 28.11.2020 | Club Olimpia | - | River Plate | 3:1 | |
Uruguay