01.04.2021 Columbus Crew (Preseason) - Toronto FC (Preseason) pas disputer
02.04.2021 18:00 FC Dallas (Preseason) - San Antonio FC 5:0
03.04.2021 Nashville SC (Preseason) - Inter Miami CF (Preseason) pas disputer
Inter Miami CF (Preseason) - New York RB (Preseason) pas disputer
17:30 Chicago Fire (Preseason) - Orlando City (Preseason) 2:2 (1:0)
19:30 Tampa Bay Rowdies (Preseason) - New York RB (Preseason) 1:3
20:00 Los Angeles FC (Preseason) - New England Revolution (Preseason) 2:2
21:00 Houston Dynamo (Preseason) - Austin FC (Preseason) 3:2
21:00 Sporting Kansas City (Preseason) - Los Angeles Galaxy (Preseason) 1:0
22:00 FC Cincinnati (Preseason) - Minnesota United (Preseason) 1:3
04.04.2021 03:00 Colorado Rapids (Preseason) - Real Salt Lake (Preseason) 0:3
21:00 D.C. United (Preseason) - New York City (Preseason) 1:2
06.04.2021 Orlando City (Preseason) - Inter Miami CF (Preseason) pas disputer
19:00 OKC Energy FC (Preseason) - Houston Dynamo (Preseason) 0:2
21:00 Vancouver Whitecaps (Preseason) - Real Monarchs SLC 0:0
07.04.2021 New England Revolution (Preseason) - Seattle Sounders (Preseason) pas disputer
Louisville City FC (Preseason) - FC Cincinnati (Preseason) pas disputer
19:00 Chicago Fire (Preseason) - Forward Madison FC (Preseason) 2:0 (1:0)
20:00 Los Angeles Galaxy II (Preseason) - New England Revolution (Preseason) 1:2
23:00 FC Dallas (Preseason) - Austin FC (Preseason) 4:2 tab
08.04.2021 Seattle Sounders (Preseason) - Los Angeles Galaxy II (Preseason) pas disputer
00:00 Colorado Rapids (Preseason) - Los Angeles Galaxy (Preseason) 2:2
03:00 Real Salt Lake (Preseason) - Phoenix Rising (Preseason) 1:0
17:00 CF Montréal (Preseason) - Tormenta FC (Preseason) 0:2
09.04.2021 22:00 Orlando City (Preseason) - Minnesota United (Preseason) 3:2
22:00 San Jose Earthquakes (Preseason) - Oakland Roots (Preseason) 3:2
10.04.2021 Nashville SC (Preseason) - Birmingham Legion (Preseason) pas disputer
18:30 Chicago Fire (Preseason) - Vancouver Whitecaps (Preseason) 2:3 (1:0)
21:00 Los Angeles FC (Preseason) - New England Revolution (Preseason) 3:3
21:00 Vancouver Whitecaps (Preseason) - Indy Eleven 0:2
21:00 Seattle Sounders (Preseason) - San Diego Loyal (Preseason) 1:0
22:00 New York RB (Preseason) - D.C. United (Preseason) 1:1
22:00 Austin FC (Preseason) - San Antonio FC 5:1
22:00 New York City (Preseason) - Hartford Athletic (Preseason) 2:0
23:00 Houston Dynamo (Preseason) - FC Dallas (Preseason) 0:3
11.04.2021 Seattle Sounders (Preseason) - Los Angeles Galaxy II (Preseason) pas disputer
02:00 Real Salt Lake (Preseason) - Los Angeles Galaxy (Preseason) 0:1
04:30 Colorado Rapids (Preseason) - Phoenix Rising (Preseason) 0:1