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| 25.06.2021 | 17:00 | Uruguay Montevideo | - | Albion | 2:2 (1:1) | |
| 19:15 | Rampla Juniors | - | Juventud de Las Piedras | 0:2 (0:2) | ||
| 21:30 | Rocha | - | Racing | 2:3 (0:0) | ||
| 23:45 | CA Cerro | - | Atenas | 1:1 (0:0) | ||
| 26.06.2021 | 02:00 | Defensor Sporting | - | Central Español | 4:0 (1:0) | |
| 17:30 | Danubio | - | Villa Teresa | 1:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing | 4 | 3 | 1 | 0 | 8:5 | 3 | 10 |
| 2 |
|
Juventud de Las Piedras | 4 | 3 | 0 | 1 | 7:3 | 4 | 9 |
| 3 |
|
Defensor Sporting | 4 | 2 | 2 | 0 | 8:3 | 5 | 8 |
| 4 |
|
Danubio | 4 | 2 | 1 | 1 | 4:3 | 1 | 7 |
| 5 |
|
Albion | 4 | 1 | 2 | 1 | 7:7 | 0 | 5 |
| 6 |
|
CA Cerro | 4 | 1 | 2 | 1 | 5:5 | 0 | 5 |
| 7 |
|
Rampla Juniors | 4 | 1 | 2 | 1 | 4:5 | -1 | 5 |
| 8 |
|
Rocha | 4 | 1 | 1 | 2 | 6:7 | -1 | 4 |
| 9 |
|
Central Español | 4 | 1 | 1 | 2 | 5:9 | -4 | 4 |
| 10 |
|
Atenas | 4 | 0 | 3 | 1 | 3:4 | -1 | 3 |
| 11 |
|
Villa Teresa | 4 | 1 | 0 | 3 | 4:7 | -3 | 3 |
| 12 |
|
Uruguay Montevideo | 4 | 0 | 1 | 3 | 4:7 | -3 | 1 |
| Promotion | |
| Play-off |
