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| H (Match allé) | Progreso | - | Defensor Sporting | 1:1 (0:0) | ||
| R (match retour) | Defensor Sporting | - | Progreso | 3:1 (0:1) | ||
| H (Match allé): 26.10.2022 21:30 | R (match retour): 04.11.2022 00:00 | vainqueur: Defensor Sporting | ||||
| H (Match allé) | Peñarol | - | La Luz | 1:0 (0:0) | ||
| R (match retour) | La Luz | - | Peñarol | 4:2 (0:0, 1:0) tab | ||
| H (Match allé): 28.10.2022 01:00 | R (match retour): 02.11.2022 00:00 | vainqueur: La Luz | ||||
