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| 04.12.2021 | 15:00 | Proleter Novi Sad | - | FK Metalac | 1:0 (1:0) | |
| 05.12.2021 | 13:30 | FK Napredak | - | Crvena Zvezda | 0:2 (0:2) | |
| 15:45 | Partizan | - | FK Novi Pazar | 2:0 (0:0) | ||
| 17:00 | Spartak Subotica | - | Mladost Lučani | 0:0 (0:0) | ||
| 06.12.2021 | 14:00 | Radnik Surdulica | - | FK Radnički 1923 | 0:0 (0:0) | |
| 16:00 | FK Čukarički | - | FK Kolubara | 5:0 (3:0) | ||
| 18:00 | TSC Bačka Topola | - | Radnički Niš | 1:1 (0:0) | ||
| 07.12.2021 | 14:00 | FK Voždovac | - | Vojvodina | 3:1 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Partizan | 19 | 17 | 2 | 0 | 53:6 | 47 | 53 |
| 2 |
|
Crvena Zvezda | 19 | 16 | 2 | 1 | 46:10 | 36 | 50 |
| 3 |
|
FK Čukarički | 19 | 9 | 7 | 3 | 35:19 | 16 | 34 |
| 4 |
|
Vojvodina | 19 | 8 | 5 | 6 | 26:24 | 2 | 29 |
| 5 |
|
FK Napredak | 19 | 8 | 3 | 8 | 23:22 | 1 | 27 |
| 6 |
|
Radnički Niš | 19 | 6 | 8 | 5 | 23:21 | 2 | 26 |
| 7 |
|
FK Voždovac | 19 | 7 | 4 | 8 | 23:24 | -1 | 25 |
| 8 |
|
Spartak Subotica | 19 | 6 | 6 | 7 | 21:31 | -10 | 24 |
| 9 |
|
Proleter Novi Sad | 19 | 7 | 3 | 9 | 15:29 | -14 | 24 |
| 10 |
|
TSC Bačka Topola | 19 | 6 | 5 | 8 | 29:28 | 1 | 23 |
| 11 |
|
Radnik Surdulica | 19 | 4 | 8 | 7 | 15:22 | -7 | 20 |
| 12 |
|
FK Kolubara | 19 | 6 | 2 | 11 | 21:42 | -21 | 20 |
| 13 |
|
Mladost Lučani | 19 | 5 | 3 | 11 | 19:29 | -10 | 18 |
| 14 |
|
FK Metalac | 19 | 4 | 4 | 11 | 23:33 | -10 | 16 |
| 15 |
|
FK Radnički 1923 | 19 | 4 | 4 | 11 | 20:36 | -16 | 16 |
| 16 |
|
FK Novi Pazar | 19 | 3 | 6 | 10 | 19:35 | -16 | 15 |
| Play-off | |
| Relégation |
