15.10.2021 19:00 Académica de Coimbra - FC Famalicão 0:4 (0:3)
19:45 União Sintrense - FC Porto 0:5 (0:2)
21:45 Os Belenenses - Sporting CP 0:4 (0:1)
16.10.2021 12:00 FC Oliveira do Hospital - Vitória Guimarães 0:1 (0:1)
16:00 Oriental Dragon - Moreirense FC 2:3 (1:0, 2:2, 2:3) ap
16:00 Berço SC - Belenenses SAD 1:2 (0:1, 1:1, 1:2) ap
16:00 AD Camacha - CD Tondela 1:2 (1:1)
16:00 Valadares Gaia - Casa Pia AC 1:3 (1:1)
16:00 SC Espinho - Caldas SC 0:1 (0:0)
16:00 Leixões SC - Vilaverdense FC 5:1 (1:0)
17:00 União Leiria - CD Santa Clara 0:2 (0:1)
19:00 Louletano - Estrela Amadora 1:2 (1:1)
21:15 CD Trofense - SL Benfica 1:2 (0:1, 1:1, 1:2) ap
17.10.2021 12:00 Varzim SC - CS Marítimo 3:2 (0:0, 1:1, 2:2) tab
15:00 Vitória Setúbal - FC Vizela 0:2 (0:2)
16:00 GD Águias do Moradal - Paços de Ferreira 0:3 (0:1)
16:00 CD Condeixa - Gil Vicente 0:5 (0:2)
16:00 UFC Moitense - Sporting Braga 0:5 (0:1)
16:00 Leça FC - FC Arouca 3:2 (1:0, 1:1, 1:1) tab
16:00 FC Felgueiras 1932 - GD Estoril 0:1 (0:1)
16:00 CD Cinfães - SC Farense 0:4 (0:3)
16:00 UD Vilafranquense - Real SC 3:2 (1:1, 1:1, 3:2) ap
16:00 CD Feirense - CD Nacional 3:1 (0:1, 1:1, 3:1) ap
16:00 FC Alverca - Anadia FC 4:1 (1:1)
16:00 CD Mafra - União Coimbra 3:0 (2:0)
16:00 União Torreense - AD Fafe 3:2 (0:1, 1:1, 1:1) tab
16:00 USC Paredes - Académico de Viseu 3:1 (1:1)
16:00 Castro Daire - SC Olhanense 4:5 (1:1, 2:2, 2:2) tab
16:00 FC Serpa - Sporting Covilhã 1:0 (0:0, 0:0, 0:0) tab
16:00 Benfica Castelo Branco - FC Penafiel 1:2 (0:1)
18:00 UD Oliveirense - Portimonense SC 4:5 (1:1, 2:2, 3:3) tab
21:00 Rio Ave FC - Boavista 4:0 (1:0)