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| H (Match allé) | Veraguas Club Deportivo | - | UD Universitario | 0:0 (0:0) | ||
| R (match retour) | UD Universitario | - | Veraguas Club Deportivo | 2:0 (0:0, 0:0) ap | ||
| H (Match allé): 15.05.2021 23:00 | R (match retour): 23.05.2021 02:00 | vainqueur: UD Universitario | ||||
| H (Match allé) | Sporting San Miguelito | - | Plaza Amador | 0:1 (0:1) | ||
| R (match retour) | Plaza Amador | - | Sporting San Miguelito | 1:1 (0:0) | ||
| H (Match allé): 17.05.2021 01:00 | R (match retour): 24.05.2021 01:00 | vainqueur: Plaza Amador | ||||
