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| H (Match allé) | Alianza | - | Atlético Chiriquí | 1:0 (1:0) | ||
| R (match retour) | Atlético Chiriquí | - | Alianza | 1:1 (0:0) | ||
| H (Match allé): 15.05.2022 03:00 | R (match retour): 22.05.2022 03:00 | vainqueur: Alianza | ||||
| H (Match allé) | Tauro FC | - | Sporting San Miguelito | 1:2 (0:1) | ||
| R (match retour) | Sporting San Miguelito | - | Tauro FC | 0:0 (0:0) | ||
| H (Match allé): 16.05.2022 01:30 | R (match retour): 23.05.2022 01:00 | vainqueur: Sporting San Miguelito | ||||
