H (Match allé) Alianza - Atlético Chiriquí 1:0 (1:0)
R (match retour) Atlético Chiriquí - Alianza -:-
H (Match allé): 15.05.2022 03:00 R (match retour): 22.05.2022
H (Match allé) Tauro FC - Sporting San Miguelito 1:2 (0:1)
R (match retour) Sporting San Miguelito - Tauro FC -:-
H (Match allé): 16.05.2022 01:30 R (match retour): 22.05.2022