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| 10.09.2021 | 19:30 | SSVg Velbert | - | TSV Meerbusch | 2:1 (1:1) | |
| 19:30 | Germania Ratingen 04/19 | - | TV Jahn Hiesfeld | 0:0 (0:0) | ||
| 12.09.2021 | 15:00 | FC Kray | - | SC Union Nettetal | 3:2 (1:1) | |
| 15:00 | 1. FC Monheim | - | Sportfreunde Niederwenigern | 0:1 (0:0) | ||
| 15:00 | Schwarz-Weiß Essen | - | SC Düsseldorf-West | 5:1 (1:1) | ||
| 15:00 | TVD Velbert | - | 1. FC Kleve | 1:0 (1:0) | ||
| 15:30 | DJK Teutonia St. Tönis | - | Cronenberger SC | 0:0 (0:0) | ||
| 15:30 | TuRU Düsseldorf | - | SpVg Schonnebeck | 3:3 (0:1) | ||
| 15:30 | 1. FC Mönchengladbach | - | SC Velbert | 0:4 (0:2) | ||
| 15:30 | FSV Duisburg | - | VfB 03 Hilden | 0:1 (0:1) | ||
| 07.10.2021 | 20:00 | SpVgg Sterkrade-Nord | - | Sportfreunde Baumberg | 1:5 (0:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
TVD Velbert | 4 | 4 | 0 | 0 | 6:2 | 4 | 12 |
| 2 |
|
SpVg Schonnebeck | 4 | 3 | 1 | 0 | 16:5 | 11 | 10 |
| 3 |
|
SSVg Velbert | 4 | 3 | 1 | 0 | 11:4 | 7 | 10 |
| 4 |
|
VfB 03 Hilden | 4 | 3 | 0 | 1 | 7:4 | 3 | 9 |
| 5 |
|
Schwarz-Weiß Essen | 4 | 3 | 0 | 1 | 10:8 | 2 | 9 |
| 6 |
|
1. FC Bocholt | 3 | 2 | 1 | 0 | 12:3 | 9 | 7 |
| 7 |
|
SC Velbert | 4 | 2 | 1 | 1 | 9:4 | 5 | 7 |
| 8 |
|
Germania Ratingen 04/19 | 4 | 2 | 1 | 1 | 6:2 | 4 | 7 |
| 9 |
|
FC Kray | 4 | 2 | 1 | 1 | 11:10 | 1 | 7 |
| 10 |
|
Cronenberger SC | 4 | 1 | 2 | 1 | 5:4 | 1 | 5 |
| 11 |
|
DJK Teutonia St. Tönis | 4 | 1 | 2 | 1 | 8:8 | 0 | 5 |
| 12 |
|
1. FC Kleve | 4 | 1 | 2 | 1 | 4:4 | 0 | 5 |
| 13 |
|
Sportfreunde Niederwenigern | 4 | 1 | 2 | 1 | 7:9 | -2 | 5 |
| 14 |
|
TuRU Düsseldorf | 4 | 1 | 2 | 1 | 8:10 | -2 | 5 |
| 15 |
|
1. FC Monheim | 4 | 1 | 1 | 2 | 3:5 | -2 | 4 |
| 16 |
|
FSV Duisburg | 3 | 1 | 0 | 2 | 5:5 | 0 | 3 |
| 17 |
|
SC Union Nettetal | 4 | 1 | 0 | 3 | 6:9 | -3 | 3 |
| 18 |
|
Sportfreunde Baumberg | 4 | 1 | 0 | 3 | 7:11 | -4 | 3 |
| 19 |
|
1. FC Mönchengladbach | 3 | 1 | 0 | 2 | 5:10 | -5 | 3 |
| 20 |
|
SC Düsseldorf-West | 4 | 0 | 1 | 3 | 5:12 | -7 | 1 |
| 21 |
|
SpVgg Sterkrade-Nord | 4 | 0 | 1 | 3 | 4:11 | -7 | 1 |
| 22 |
|
TV Jahn Hiesfeld | 4 | 0 | 1 | 3 | 3:10 | -7 | 1 |
| 23 |
|
TSV Meerbusch | 3 | 0 | 0 | 3 | 3:11 | -8 | 0 |
| Play-off | |
| Play-off |
