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| 04.02.2022 | 20:00 | FC Dordrecht | - | Almere City FC | 2:2 (0:2) | |
| 20:00 | FC Emmen | - | TOP Oss | 3:1 (1:0) | ||
| 20:00 | FC Volendam | - | FC Utrecht (J) | 2:0 (2:0) | ||
| 20:00 | Jong Ajax | - | AZ Alkmaar (J) | 2:1 (1:0) | ||
| 20:00 | Jong PSV | - | Helmond Sport | 2:0 (1:0) | ||
| 20:00 | MVV | - | VVV-Venlo | 0:5 (0:4) | ||
| 20:00 | NAC Breda | - | Roda JC Kerkrade | 2:2 (0:0) | ||
| 20:00 | Telstar | - | De Graafschap | 0:3 (0:3) | ||
| 06.02.2022 | 12:15 | FC Den Bosch | - | ADO Den Haag | 0:1 (0:0) | |
| 07.02.2022 | 20:00 | FC Eindhoven | - | SBV Excelsior | 4:1 (3:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Volendam | 25 | 16 | 8 | 1 | 56:29 | 27 | 56 |
| 2 |
|
FC Emmen | 25 | 16 | 3 | 6 | 39:18 | 21 | 51 |
| 3 |
|
Jong Ajax | 25 | 15 | 4 | 6 | 53:35 | 18 | 49 |
| 4 |
|
ADO Den Haag | 25 | 17 | 3 | 5 | 54:31 | 23 | 48 |
| 5 |
|
FC Eindhoven | 25 | 13 | 5 | 7 | 45:29 | 16 | 44 |
| 6 |
|
De Graafschap | 25 | 13 | 5 | 7 | 38:25 | 13 | 44 |
| 7 |
|
SBV Excelsior | 25 | 13 | 4 | 8 | 51:37 | 14 | 43 |
| 8 |
|
Roda JC Kerkrade | 25 | 11 | 9 | 5 | 51:31 | 20 | 42 |
| 9 |
|
Jong PSV | 25 | 10 | 5 | 10 | 43:36 | 7 | 35 |
| 10 |
|
NAC Breda | 25 | 8 | 9 | 8 | 36:31 | 5 | 33 |
| 11 |
|
VVV-Venlo | 25 | 10 | 2 | 13 | 35:37 | -2 | 32 |
| 12 |
|
TOP Oss | 25 | 7 | 6 | 12 | 30:40 | -10 | 27 |
| 13 |
|
Telstar | 25 | 6 | 9 | 10 | 26:45 | -19 | 27 |
| 14 |
|
FC Den Bosch | 25 | 8 | 2 | 15 | 27:46 | -19 | 26 |
| 15 |
|
AZ Alkmaar (J) | 25 | 7 | 4 | 14 | 22:32 | -10 | 25 |
| 16 |
|
FC Utrecht (J) | 25 | 7 | 4 | 14 | 27:47 | -20 | 25 |
| 17 |
|
MVV | 25 | 7 | 2 | 16 | 23:50 | -27 | 23 |
| 18 |
|
FC Dordrecht | 25 | 5 | 6 | 14 | 35:56 | -21 | 21 |
| 19 |
|
Helmond Sport | 25 | 6 | 5 | 14 | 24:41 | -17 | 20 |
| 20 |
|
Almere City FC | 25 | 4 | 7 | 14 | 36:55 | -19 | 19 |
| Promotion | |
| Play-off | |
| Play-off |
