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|
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| 14.01.2022 | 20:00 | Almere City FC | - | Roda JC Kerkrade | 0:4 (0:3) | |
| 20:00 | FC Eindhoven | - | FC Utrecht (J) | 4:0 (0:0) | ||
| 20:00 | SBV Excelsior | - | De Graafschap | 0:0 (0:0) | ||
| 20:00 | NAC Breda | - | FC Volendam | 0:0 (0:0) | ||
| 20:00 | Telstar | - | MVV | 2:1 (2:0) | ||
| 20:00 | VVV-Venlo | - | Jong PSV | 1:4 (1:1) | ||
| 15.01.2022 | 16:30 | ADO Den Haag | - | TOP Oss | 2:0 (0:0) | |
| 17.01.2022 | 20:00 | FC Dordrecht | - | AZ Alkmaar (J) | 2:0 (1:0) | |
| 20:00 | Jong Ajax | - | FC Den Bosch | 2:1 (1:0) | ||
| 01.03.2022 | 20:00 | FC Emmen | - | Helmond Sport | 1:2 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Volendam | 22 | 14 | 7 | 1 | 52:28 | 24 | 49 |
| 2 |
|
ADO Den Haag | 22 | 16 | 2 | 4 | 53:26 | 27 | 44 |
| 3 |
|
SBV Excelsior | 22 | 13 | 4 | 5 | 50:29 | 21 | 43 |
| 4 |
|
Jong Ajax | 22 | 13 | 4 | 5 | 49:33 | 16 | 43 |
| 5 |
|
FC Emmen | 22 | 13 | 3 | 6 | 33:17 | 16 | 42 |
| 6 |
|
Roda JC Kerkrade | 22 | 10 | 7 | 5 | 43:28 | 15 | 37 |
| 7 |
|
De Graafschap | 22 | 11 | 4 | 7 | 34:25 | 9 | 37 |
| 8 |
|
FC Eindhoven | 22 | 10 | 5 | 7 | 38:28 | 10 | 35 |
| 9 |
|
NAC Breda | 22 | 7 | 8 | 7 | 32:27 | 5 | 29 |
| 10 |
|
Jong PSV | 22 | 8 | 5 | 9 | 38:34 | 4 | 29 |
| 11 |
|
VVV-Venlo | 22 | 8 | 2 | 12 | 26:33 | -7 | 26 |
| 12 |
|
FC Den Bosch | 22 | 8 | 2 | 12 | 26:41 | -15 | 26 |
| 13 |
|
Telstar | 22 | 5 | 8 | 9 | 25:42 | -17 | 23 |
| 14 |
|
MVV | 22 | 7 | 2 | 13 | 23:43 | -20 | 23 |
| 15 |
|
AZ Alkmaar (J) | 22 | 6 | 4 | 12 | 19:28 | -9 | 22 |
| 16 |
|
FC Utrecht (J) | 22 | 6 | 4 | 12 | 24:39 | -15 | 22 |
| 17 |
|
TOP Oss | 22 | 5 | 6 | 11 | 24:35 | -11 | 21 |
| 18 |
|
Helmond Sport | 22 | 6 | 5 | 11 | 21:33 | -12 | 20 |
| 19 |
|
Almere City FC | 22 | 4 | 5 | 13 | 34:52 | -18 | 17 |
| 20 |
|
FC Dordrecht | 22 | 4 | 5 | 13 | 27:50 | -23 | 17 |
| Promotion | |
| Play-off | |
| Play-off |
