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| 07.01.2022 | 18:45 | Helmond Sport | - | FC Dordrecht | 1:2 (0:0) | |
| 21:00 | Roda JC Kerkrade | - | MVV | 1:0 (0:0) | ||
| 08.01.2022 | 18:45 | FC Den Bosch | - | FC Emmen | 0:2 (0:1) | |
| 21:00 | NAC Breda | - | FC Eindhoven | 0:0 (0:0) | ||
| 09.01.2022 | 12:15 | FC Volendam | - | Telstar | 2:1 (2:1) | |
| 16:45 | De Graafschap | - | VVV-Venlo | 1:2 (0:1) | ||
| 10.01.2022 | 18:45 | FC Utrecht (J) | - | Jong Ajax | 0:2 (0:1) | |
| 21:00 | Jong PSV | - | Almere City FC | 5:1 (3:1) | ||
| 24.01.2022 | 20:00 | TOP Oss | - | AZ Alkmaar (J) | 1:0 (0:0) | |
| 25.01.2022 | 20:00 | SBV Excelsior | - | ADO Den Haag | 2:3 (1:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Volendam | 21 | 14 | 6 | 1 | 52:28 | 24 | 48 |
| 2 |
|
SBV Excelsior | 21 | 13 | 3 | 5 | 50:29 | 21 | 42 |
| 3 |
|
FC Emmen | 21 | 13 | 3 | 5 | 32:15 | 17 | 42 |
| 4 |
|
ADO Den Haag | 21 | 15 | 2 | 4 | 51:26 | 25 | 41 |
| 5 |
|
Jong Ajax | 21 | 12 | 4 | 5 | 47:32 | 15 | 40 |
| 6 |
|
De Graafschap | 21 | 11 | 3 | 7 | 34:25 | 9 | 36 |
| 7 |
|
Roda JC Kerkrade | 21 | 9 | 7 | 5 | 39:28 | 11 | 34 |
| 8 |
|
FC Eindhoven | 21 | 9 | 5 | 7 | 34:28 | 6 | 32 |
| 9 |
|
NAC Breda | 21 | 7 | 7 | 7 | 32:27 | 5 | 28 |
| 10 |
|
Jong PSV | 21 | 7 | 5 | 9 | 34:33 | 1 | 26 |
| 11 |
|
VVV-Venlo | 21 | 8 | 2 | 11 | 25:29 | -4 | 26 |
| 12 |
|
FC Den Bosch | 21 | 8 | 2 | 11 | 25:39 | -14 | 26 |
| 13 |
|
MVV | 21 | 7 | 2 | 12 | 22:41 | -19 | 23 |
| 14 |
|
AZ Alkmaar (J) | 21 | 6 | 4 | 11 | 19:26 | -7 | 22 |
| 15 |
|
FC Utrecht (J) | 21 | 6 | 4 | 11 | 24:35 | -11 | 22 |
| 16 |
|
TOP Oss | 21 | 5 | 6 | 10 | 24:33 | -9 | 21 |
| 17 |
|
Telstar | 21 | 4 | 8 | 9 | 23:41 | -18 | 20 |
| 18 |
|
Helmond Sport | 21 | 5 | 5 | 11 | 19:32 | -13 | 17 |
| 19 |
|
Almere City FC | 21 | 4 | 5 | 12 | 34:48 | -14 | 17 |
| 20 |
|
FC Dordrecht | 21 | 3 | 5 | 13 | 25:50 | -25 | 14 |
| Promotion | |
| Play-off | |
| Play-off |
