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| 07.05.2021 | 20:00 | FC Den Bosch | - | Telstar | 4:1 (2:0) | |
| 20:00 | FC Dordrecht | - | SC Cambuur | 0:1 (0:1) | ||
| 20:00 | Go Ahead Eagles | - | NEC Nijmegen | 2:1 (2:1) | ||
| 20:00 | Helmond Sport | - | TOP Oss | 1:1 (0:1) | ||
| 20:00 | Jong Ajax | - | De Graafschap | 1:1 (1:0) | ||
| 20:00 | AZ Alkmaar (J) | - | SBV Excelsior | 2:1 (2:1) | ||
| 20:00 | FC Utrecht (J) | - | Almere City FC | 1:3 (0:2) | ||
| 20:00 | Jong PSV | - | FC Volendam | 0:1 (0:0) | ||
| 20:00 | NAC Breda | - | MVV | 2:0 (1:0) | ||
| 20:00 | Roda JC Kerkrade | - | FC Eindhoven | 2:1 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Cambuur | 37 | 28 | 5 | 4 | 106:34 | 72 | 89 |
| 2 |
|
De Graafschap | 37 | 23 | 7 | 7 | 67:47 | 20 | 76 |
| 3 |
|
Go Ahead Eagles | 37 | 22 | 8 | 7 | 61:25 | 36 | 74 |
| 4 |
|
Almere City FC | 37 | 22 | 8 | 7 | 74:47 | 27 | 74 |
| 5 |
|
NAC Breda | 37 | 22 | 7 | 8 | 73:38 | 35 | 73 |
| 6 |
|
FC Volendam | 37 | 18 | 9 | 10 | 77:51 | 26 | 63 |
| 7 |
|
NEC Nijmegen | 37 | 19 | 6 | 12 | 66:44 | 22 | 63 |
| 8 |
|
Roda JC Kerkrade | 37 | 15 | 12 | 10 | 67:59 | 8 | 57 |
| 9 |
|
SBV Excelsior | 37 | 14 | 6 | 17 | 65:65 | 0 | 48 |
| 10 |
|
Helmond Sport | 37 | 11 | 11 | 15 | 51:68 | -17 | 44 |
| 11 |
|
TOP Oss | 37 | 12 | 8 | 17 | 38:57 | -19 | 44 |
| 12 |
|
MVV | 37 | 12 | 7 | 18 | 47:71 | -24 | 43 |
| 13 |
|
Telstar | 37 | 10 | 11 | 16 | 56:59 | -3 | 41 |
| 14 |
|
Jong PSV | 37 | 10 | 9 | 18 | 53:64 | -11 | 39 |
| 15 |
|
FC Eindhoven | 37 | 10 | 9 | 18 | 48:60 | -12 | 39 |
| 16 |
|
AZ Alkmaar (J) | 37 | 11 | 5 | 21 | 55:90 | -35 | 38 |
| 17 |
|
Jong Ajax | 37 | 9 | 10 | 18 | 53:70 | -17 | 37 |
| 18 |
|
FC Utrecht (J) | 37 | 11 | 1 | 25 | 51:75 | -24 | 34 |
| 19 |
|
FC Den Bosch | 37 | 8 | 8 | 21 | 58:82 | -24 | 32 |
| 20 |
|
FC Dordrecht | 37 | 8 | 3 | 26 | 35:95 | -60 | 27 |
| Promotion | |
| Play-off |
