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| 12.03.2021 | 14:00 | MVV | - | AZ Alkmaar (J) | 3:2 (1:1) | |
| 16:30 | FC Eindhoven | - | Almere City FC | 1:3 (1:3) | ||
| 18:45 | FC Den Bosch | - | FC Volendam | 1:5 (0:1) | ||
| 18:45 | FC Dordrecht | - | TOP Oss | 1:3 (0:1) | ||
| 18:45 | SBV Excelsior | - | FC Utrecht (J) | 2:0 (1:0) | ||
| 18:45 | NEC Nijmegen | - | Jong PSV | 2:0 (0:0) | ||
| 21:00 | Go Ahead Eagles | - | SC Cambuur | 0:0 (0:0) | ||
| 21:00 | NAC Breda | - | Helmond Sport | 3:2 (0:1) | ||
| 21:00 | Roda JC Kerkrade | - | Jong Ajax | 2:2 (1:0) | ||
| 21:00 | Telstar | - | De Graafschap | 1:2 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Cambuur | 28 | 21 | 4 | 3 | 77:22 | 55 | 67 |
| 2 |
|
De Graafschap | 28 | 20 | 3 | 5 | 57:36 | 21 | 63 |
| 3 |
|
NAC Breda | 28 | 18 | 5 | 5 | 57:27 | 30 | 59 |
| 4 |
|
Almere City FC | 28 | 18 | 5 | 5 | 63:38 | 25 | 59 |
| 5 |
|
Go Ahead Eagles | 28 | 16 | 6 | 6 | 41:18 | 23 | 54 |
| 6 |
|
NEC Nijmegen | 28 | 16 | 5 | 7 | 57:31 | 26 | 53 |
| 7 |
|
FC Volendam | 28 | 13 | 8 | 7 | 62:39 | 23 | 47 |
| 8 |
|
Roda JC Kerkrade | 28 | 12 | 9 | 7 | 54:41 | 13 | 45 |
| 9 |
|
SBV Excelsior | 28 | 11 | 3 | 14 | 53:49 | 4 | 36 |
| 10 |
|
Telstar | 28 | 9 | 7 | 12 | 45:43 | 2 | 34 |
| 11 |
|
MVV | 28 | 9 | 5 | 14 | 32:54 | -22 | 32 |
| 12 |
|
Jong Ajax | 28 | 8 | 7 | 13 | 45:56 | -11 | 31 |
| 13 |
|
TOP Oss | 28 | 9 | 4 | 15 | 30:48 | -18 | 31 |
| 14 |
|
Helmond Sport | 28 | 7 | 9 | 12 | 38:51 | -13 | 30 |
| 15 |
|
FC Eindhoven | 28 | 7 | 8 | 13 | 38:49 | -11 | 29 |
| 16 |
|
FC Utrecht (J) | 28 | 9 | 1 | 18 | 38:54 | -16 | 28 |
| 17 |
|
Jong PSV | 28 | 6 | 6 | 16 | 37:57 | -20 | 24 |
| 18 |
|
AZ Alkmaar (J) | 28 | 6 | 5 | 17 | 40:75 | -35 | 23 |
| 19 |
|
FC Dordrecht | 28 | 6 | 3 | 19 | 27:70 | -43 | 21 |
| 20 |
|
FC Den Bosch | 28 | 4 | 7 | 17 | 33:66 | -33 | 19 |
| Promotion | |
| Play-off |
