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| 05.03.2021 | 18:45 | Helmond Sport | - | NEC Nijmegen | 0:7 (0:3) | |
| 18:45 | FC Utrecht (J) | - | MVV | 0:1 (0:1) | ||
| 21:00 | TOP Oss | - | Go Ahead Eagles | 0:4 (0:1) | ||
| 21:00 | SC Cambuur | - | Telstar | 3:1 (2:1) | ||
| 06.03.2021 | 14:00 | Almere City FC | - | SBV Excelsior | 4:1 (2:0) | |
| 16:30 | FC Volendam | - | Roda JC Kerkrade | 3:4 (2:1) | ||
| 07.03.2021 | 20:00 | De Graafschap | - | FC Eindhoven | 1:0 (0:0) | |
| 08.03.2021 | 18:45 | Jong Ajax | - | FC Den Bosch | 1:2 (1:1) | |
| 21:00 | AZ Alkmaar (J) | - | NAC Breda | 2:3 (0:2) | ||
| 09.03.2021 | 21:00 | Jong PSV | - | FC Dordrecht | 0:1 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Cambuur | 27 | 21 | 3 | 3 | 77:22 | 55 | 66 |
| 2 |
|
De Graafschap | 27 | 19 | 3 | 5 | 55:35 | 20 | 60 |
| 3 |
|
NAC Breda | 27 | 17 | 5 | 5 | 54:25 | 29 | 56 |
| 4 |
|
Almere City FC | 27 | 17 | 5 | 5 | 60:37 | 23 | 56 |
| 5 |
|
Go Ahead Eagles | 27 | 16 | 5 | 6 | 41:18 | 23 | 53 |
| 6 |
|
NEC Nijmegen | 27 | 15 | 5 | 7 | 55:31 | 24 | 50 |
| 7 |
|
FC Volendam | 27 | 12 | 8 | 7 | 57:38 | 19 | 44 |
| 8 |
|
Roda JC Kerkrade | 27 | 12 | 8 | 7 | 52:39 | 13 | 44 |
| 9 |
|
Telstar | 27 | 9 | 7 | 11 | 44:41 | 3 | 34 |
| 10 |
|
SBV Excelsior | 27 | 10 | 3 | 14 | 51:49 | 2 | 33 |
| 11 |
|
Jong Ajax | 27 | 8 | 6 | 13 | 43:54 | -11 | 30 |
| 12 |
|
Helmond Sport | 27 | 7 | 9 | 11 | 36:48 | -12 | 30 |
| 13 |
|
FC Eindhoven | 27 | 7 | 8 | 12 | 37:46 | -9 | 29 |
| 14 |
|
MVV | 27 | 8 | 5 | 14 | 29:52 | -23 | 29 |
| 15 |
|
FC Utrecht (J) | 27 | 9 | 1 | 17 | 38:52 | -14 | 28 |
| 16 |
|
TOP Oss | 27 | 8 | 4 | 15 | 27:47 | -20 | 28 |
| 17 |
|
Jong PSV | 27 | 6 | 6 | 15 | 37:55 | -18 | 24 |
| 18 |
|
AZ Alkmaar (J) | 27 | 6 | 5 | 16 | 38:72 | -34 | 23 |
| 19 |
|
FC Dordrecht | 27 | 6 | 3 | 18 | 26:67 | -41 | 21 |
| 20 |
|
FC Den Bosch | 27 | 4 | 7 | 16 | 32:61 | -29 | 19 |
| Promotion | |
| Play-off |
