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| 29.01.2021 | 18:45 | Helmond Sport | - | Telstar | 1:1 (1:0) | |
| 18:45 | Jong PSV | - | Jong Ajax | 1:2 (0:1) | ||
| 21:00 | De Graafschap | - | TOP Oss | 2:1 (1:0) | ||
| 21:00 | NEC Nijmegen | - | FC Utrecht (J) | 2:0 (0:0) | ||
| 30.01.2021 | 14:00 | SBV Excelsior | - | FC Den Bosch | 4:4 (2:0) | |
| 16:30 | FC Dordrecht | - | Roda JC Kerkrade | 0:5 (0:3) | ||
| 31.01.2021 | 20:00 | SC Cambuur | - | MVV | 2:0 (0:0) | |
| 01.02.2021 | 18:45 | AZ Alkmaar (J) | - | FC Eindhoven | 3:2 (0:1) | |
| 21:00 | NAC Breda | - | Almere City FC | 4:0 (2:0) | ||
| 02.02.2021 | 18:45 | Go Ahead Eagles | - | FC Volendam | 1:3 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Cambuur | 22 | 17 | 2 | 3 | 65:19 | 46 | 53 |
| 2 |
|
Almere City FC | 22 | 15 | 5 | 2 | 50:28 | 22 | 50 |
| 3 |
|
De Graafschap | 22 | 15 | 2 | 5 | 47:31 | 16 | 47 |
| 4 |
|
NAC Breda | 22 | 12 | 5 | 5 | 41:19 | 22 | 41 |
| 5 |
|
NEC Nijmegen | 22 | 12 | 5 | 5 | 39:25 | 14 | 41 |
| 6 |
|
Go Ahead Eagles | 22 | 11 | 5 | 6 | 30:18 | 12 | 38 |
| 7 |
|
FC Volendam | 22 | 10 | 7 | 5 | 48:28 | 20 | 37 |
| 8 |
|
Telstar | 22 | 9 | 6 | 7 | 41:32 | 9 | 33 |
| 9 |
|
Roda JC Kerkrade | 22 | 8 | 8 | 6 | 37:30 | 7 | 32 |
| 10 |
|
Jong Ajax | 22 | 8 | 5 | 9 | 37:41 | -4 | 29 |
| 11 |
|
SBV Excelsior | 22 | 8 | 3 | 11 | 42:40 | 2 | 27 |
| 12 |
|
FC Eindhoven | 22 | 7 | 6 | 9 | 34:39 | -5 | 27 |
| 13 |
|
Helmond Sport | 22 | 6 | 8 | 8 | 30:34 | -4 | 26 |
| 14 |
|
FC Utrecht (J) | 22 | 8 | 1 | 13 | 32:41 | -9 | 25 |
| 15 |
|
TOP Oss | 22 | 7 | 4 | 11 | 19:33 | -14 | 25 |
| 16 |
|
Jong PSV | 22 | 5 | 5 | 12 | 33:46 | -13 | 20 |
| 17 |
|
AZ Alkmaar (J) | 22 | 5 | 4 | 13 | 32:57 | -25 | 19 |
| 18 |
|
MVV | 22 | 4 | 5 | 13 | 23:50 | -27 | 17 |
| 19 |
|
FC Den Bosch | 22 | 2 | 7 | 13 | 24:52 | -28 | 13 |
| 20 |
|
FC Dordrecht | 22 | 3 | 3 | 16 | 18:59 | -41 | 12 |
| Promotion | |
| Play-off |
