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| 23.10.2021 | 14:00 | KF Shkupi | - | FK Renova | 2:1 (0:0) | |
| 24.10.2021 | 14:00 | FK Borec | - | Akademija Pandev | 1:2 (0:1) | |
| 14:00 | FK Pelister | - | FK Bregalnica Štip | 0:3 (0:1) | ||
| 14:00 | FK Skopje | - | GFK Tikvesh | 2:1 (1:0) | ||
| 14:00 | KF Shkëndija 79 | - | FK Rabotnički | 2:0 (1:0) | ||
| 14:00 | Makedonija GP | - | FC Struga | 1:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 11 | 8 | 2 | 1 | 21:7 | 14 | 26 |
| 2 |
|
FK Renova | 11 | 6 | 3 | 2 | 19:10 | 9 | 21 |
| 3 |
|
Akademija Pandev | 11 | 6 | 3 | 2 | 18:11 | 7 | 21 |
| 4 |
|
FK Bregalnica Štip | 11 | 5 | 4 | 2 | 19:14 | 5 | 19 |
| 5 |
|
KF Shkëndija 79 | 11 | 4 | 5 | 2 | 19:10 | 9 | 17 |
| 6 |
|
FC Struga | 11 | 3 | 6 | 2 | 11:9 | 2 | 15 |
| 7 |
|
FK Rabotnički | 11 | 4 | 3 | 4 | 9:10 | -1 | 15 |
| 8 |
|
FK Skopje | 11 | 4 | 3 | 4 | 9:14 | -5 | 15 |
| 9 |
|
Makedonija GP | 11 | 3 | 2 | 6 | 13:24 | -11 | 11 |
| 10 |
|
FK Borec | 11 | 2 | 2 | 7 | 9:20 | -11 | 8 |
| 11 |
|
GFK Tikvesh | 11 | 1 | 3 | 7 | 7:14 | -7 | 6 |
| 12 |
|
FK Pelister | 11 | 0 | 4 | 7 | 4:15 | -11 | 4 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
