 |
 |
|
|
| 11.09.2021 | 02:00 | Puebla FC | - | Atlético San Luis | 2:2 (0:1) | |
| 04:00 | FC Juárez | - | Cruz Azul | 2:1 (2:1) | ||
| 04:06 | Club Tijuana | - | Santos Laguna | 2:1 (1:0) | ||
| 12.09.2021 | 00:00 | Atlas Guadalajara | - | CF Monterrey | 2:1 (0:1) | |
| 02:00 | UANL Tigres | - | Club León | 2:2 (1:2) | ||
| 04:00 | CF América | - | Mazatlán FC | 2:0 (1:0) | ||
| 13.09.2021 | 00:00 | Pumas UNAM | - | Deportivo Guadalajara | 0:0 (0:0) | |
| 02:00 | Gallos Blancos | - | Club Necaxa | 3:0 (2:0) | ||
| 14.09.2021 | 04:00 | CF Pachuca | - | Deportivo Toluca | 1:2 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 8 | 6 | 2 | 0 | 12:3 | 9 | 20 |
| 2 |
|
Deportivo Toluca | 8 | 5 | 2 | 1 | 14:10 | 4 | 17 |
| 3 |
|
Club León | 8 | 4 | 3 | 1 | 13:9 | 4 | 15 |
| 4 |
|
UANL Tigres | 8 | 3 | 4 | 1 | 14:9 | 5 | 13 |
| 5 |
|
Atlas Guadalajara | 8 | 3 | 4 | 1 | 7:4 | 3 | 13 |
| 6 |
|
Santos Laguna | 8 | 2 | 5 | 1 | 10:6 | 4 | 11 |
| 7 |
|
CF Monterrey | 8 | 2 | 5 | 1 | 11:8 | 3 | 11 |
| 8 |
|
Atlético San Luis | 8 | 2 | 5 | 1 | 10:9 | 1 | 11 |
| 9 |
|
Cruz Azul | 8 | 2 | 4 | 2 | 10:8 | 2 | 10 |
| 10 |
|
Deportivo Guadalajara | 8 | 2 | 4 | 2 | 7:8 | -1 | 10 |
| 11 |
|
Club Necaxa | 8 | 3 | 0 | 5 | 9:12 | -3 | 9 |
| 12 |
|
Mazatlán FC | 8 | 2 | 3 | 3 | 9:14 | -5 | 9 |
| 13 |
|
CF Pachuca | 8 | 2 | 2 | 4 | 10:9 | 1 | 8 |
| 14 |
|
Puebla FC | 8 | 1 | 4 | 3 | 6:11 | -5 | 7 |
| 15 |
|
Gallos Blancos | 8 | 1 | 3 | 4 | 4:8 | -4 | 6 |
| 16 |
|
Club Tijuana | 8 | 1 | 3 | 4 | 8:13 | -5 | 6 |
| 17 |
|
Pumas UNAM | 8 | 1 | 3 | 4 | 4:10 | -6 | 6 |
| 18 |
|
FC Juárez | 8 | 1 | 2 | 5 | 7:14 | -7 | 5 |
| Play-off | |
| Play-off |
