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| H (Match allé) | Club Irapuato | - | Cruz Azul Hidalgo | 2:0 (0:0) | ||
| R (match retour) | Cruz Azul Hidalgo | - | Club Irapuato | 1:1 (1:0) | ||
| H (Match allé): 10.05.2021 02:30 | R (match retour): 16.05.2021 19:00 | vainqueur: Club Irapuato | ||||
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| H (Match allé) | Club Irapuato | - | Cruz Azul Hidalgo | 2:0 (0:0) | ||
| R (match retour) | Cruz Azul Hidalgo | - | Club Irapuato | 1:1 (1:0) | ||
| H (Match allé): 10.05.2021 02:30 | R (match retour): 16.05.2021 19:00 | vainqueur: Club Irapuato | ||||
