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| H (Match allé) | Club Calor | - | Mazorqueros | 1:0 (1:0) | ||
| R (match retour) | Mazorqueros | - | Club Calor | 0:2 (0:1) | ||
| H (Match allé): 03.11.2022 02:00 | R (match retour): 05.11.2022 23:00 | vainqueur: Club Calor | ||||
| H (Match allé) | Pioneros de Cancún | - | Alebrijes de Oaxaca II | 1:2 (0:1) | ||
| R (match retour) | Alebrijes de Oaxaca II | - | Pioneros de Cancún | 1:0 (0:0) | ||
| H (Match allé): 03.11.2022 02:00 | R (match retour): 06.11.2022 01:00 | vainqueur: Alebrijes de Oaxaca II | ||||
