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| H (Match allé) | CF Pachuca | - | CF Monterrey | 2:0 (2:0) | ||
| R (match retour) | CF Monterrey | - | CF Pachuca | 2:1 (0:0) | ||
| H (Match allé): 14.05.2022 01:05 | R (match retour): 17.05.2022 04:05 | vainqueur: CF Pachuca | ||||
| H (Match allé) | UANL Tigres | - | Deportivo Guadalajara | 2:0 (0:0) | ||
| R (match retour) | Deportivo Guadalajara | - | UANL Tigres | 2:0 (1:0) | ||
| H (Match allé): 14.05.2022 03:05 | R (match retour): 17.05.2022 02:00 | |||||
