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| 20.02.2022 | 14:30 | Castelnuovo Vomano | - | GSD Castelfidardo | 2:1 | |
| 14:30 | Alma Juventus Fano | - | Chieti Calcio | 0:1 | ||
| 14:30 | Atletico Terme Fiuggi | - | Montegiorgio Calcio | 0:3 | ||
| 14:30 | Nereto | - | Tolentino | 2:2 | ||
| 14:30 | US Recanatese | - | Aurora Alto Casertano | 6:0 | ||
| 14:30 | ASD Trastevere | - | ASD Pineto Calcio | 0:2 | ||
| 14:30 | Vastese Calcio | - | Matese | 1:3 | ||
| 14:30 | Vastogirardi | - | SN Notaresco | 2:0 | ||
| 14:30 | Porto D'Ascoli | - | Sambenedettese | 2:3 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
US Recanatese | 21 | 13 | 5 | 3 | 44:13 | 31 | 44 |
| 2 |
|
ASD Trastevere | 21 | 12 | 3 | 6 | 35:20 | 15 | 39 |
| 3 |
|
ASD Pineto Calcio | 21 | 9 | 8 | 4 | 29:14 | 15 | 35 |
| 4 |
|
Atletico Terme Fiuggi | 21 | 11 | 2 | 8 | 28:27 | 1 | 35 |
| 5 |
|
Chieti Calcio | 21 | 9 | 6 | 6 | 23:21 | 2 | 33 |
| 6 |
|
Porto D'Ascoli | 21 | 9 | 6 | 6 | 25:21 | 4 | 33 |
| 7 |
|
Vastese Calcio | 21 | 8 | 8 | 5 | 31:23 | 8 | 32 |
| 8 |
|
Tolentino | 21 | 9 | 5 | 7 | 23:17 | 6 | 32 |
| 9 |
|
Vastogirardi | 21 | 9 | 5 | 7 | 32:33 | -1 | 32 |
| 10 |
|
SN Notaresco | 21 | 9 | 5 | 7 | 27:27 | 0 | 32 |
| 11 |
|
Sambenedettese | 21 | 8 | 5 | 8 | 23:26 | -3 | 29 |
| 12 |
|
Matese | 21 | 7 | 8 | 6 | 26:23 | 3 | 29 |
| 13 |
|
Montegiorgio Calcio | 21 | 8 | 4 | 9 | 25:24 | 1 | 28 |
| 14 |
|
Alma Juventus Fano | 21 | 7 | 5 | 9 | 24:24 | 0 | 26 |
| 15 |
|
GSD Castelfidardo | 21 | 6 | 5 | 10 | 17:22 | -5 | 23 |
| 16 |
|
Castelnuovo Vomano | 21 | 6 | 5 | 10 | 30:37 | -7 | 23 |
| 17 |
|
Nereto | 21 | 2 | 6 | 13 | 19:46 | -27 | 12 |
| 18 |
|
Aurora Alto Casertano | 21 | 0 | 3 | 18 | 5:48 | -43 | 3 |
| Promotion | |
| Play-off | |
| Relégation | |
| Relégation |
