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| 05.12.2021 | 14:30 | Aurora Alto Casertano | - | GSD Castelfidardo | 0:1 | |
| 14:30 | ASD Pineto Calcio | - | Matese | 0:0 | ||
| 14:30 | Atletico Terme Fiuggi | - | Vastogirardi | 4:2 | ||
| 14:30 | Montegiorgio Calcio | - | Chieti Calcio | 0:2 | ||
| 14:30 | Nereto | - | Porto D'Ascoli | 1:2 | ||
| 14:30 | US Recanatese | - | Vastese Calcio | 3:1 | ||
| 14:30 | ASD Trastevere | - | Alma Juventus Fano | 3:1 | ||
| 14:30 | Tolentino | - | SN Notaresco | 2:0 | ||
| 14:30 | Sambenedettese | - | Castelnuovo Vomano | 2:0 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
ASD Trastevere | 12 | 10 | 0 | 2 | 24:7 | 17 | 30 |
| 2 |
|
US Recanatese | 12 | 8 | 3 | 1 | 25:10 | 15 | 27 |
| 3 |
|
Atletico Terme Fiuggi | 12 | 8 | 2 | 2 | 20:10 | 10 | 26 |
| 4 |
|
SN Notaresco | 12 | 7 | 2 | 3 | 19:14 | 5 | 23 |
| 5 |
|
Porto D'Ascoli | 12 | 6 | 3 | 3 | 13:9 | 4 | 21 |
| 6 |
|
GSD Castelfidardo | 12 | 6 | 2 | 4 | 13:10 | 3 | 20 |
| 7 |
|
ASD Pineto Calcio | 12 | 5 | 4 | 3 | 19:8 | 11 | 19 |
| 8 |
|
Tolentino | 12 | 6 | 1 | 5 | 15:10 | 5 | 19 |
| 9 |
|
Matese | 12 | 4 | 5 | 3 | 12:10 | 2 | 17 |
| 10 |
|
Castelnuovo Vomano | 12 | 4 | 3 | 5 | 19:20 | -1 | 15 |
| 11 |
|
Vastogirardi | 12 | 4 | 3 | 5 | 16:22 | -6 | 15 |
| 12 |
|
Chieti Calcio | 12 | 3 | 5 | 4 | 9:12 | -3 | 14 |
| 13 |
|
Alma Juventus Fano | 12 | 3 | 3 | 6 | 14:16 | -2 | 12 |
| 14 |
|
Vastese Calcio | 12 | 2 | 6 | 4 | 11:14 | -3 | 12 |
| 15 |
|
Sambenedettese | 12 | 3 | 2 | 7 | 11:19 | -8 | 11 |
| 16 |
|
Montegiorgio Calcio | 12 | 3 | 2 | 7 | 10:18 | -8 | 11 |
| 17 |
|
Nereto | 12 | 1 | 2 | 9 | 9:28 | -19 | 5 |
| 18 |
|
Aurora Alto Casertano | 12 | 0 | 2 | 10 | 1:23 | -22 | 2 |
| Promotion | |
| Play-off | |
| Relégation | |
| Relégation |
