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| 13.02.2022 | 14:30 | Cascina | - | Foligno Calcio | 1:2 | |
| 14:30 | ASD Cannara | - | Scandicci Calcio | 1:2 | ||
| 14:30 | Virtus Flaminia | - | US Pianese | 2:2 | ||
| 14:30 | Follonica Gavorrano | - | AC Sangiovannese | 1:1 | ||
| 14:30 | Badesse Calcio | - | US Poggibonsi | 0:2 | ||
| 14:30 | Montespaccato | - | US Arezzo | 1:1 | ||
| 14:30 | FC Rieti | - | San Donato Tavarnelle | 2:1 | ||
| 14:30 | SC Trestina | - | SSD Tiferno Lerchi | 1:1 | ||
| 14:30 | Unipomezia Virtus | - | Pro Livorno Sorgenti | 2:1 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
San Donato Tavarnelle | 20 | 15 | 2 | 3 | 57:21 | 36 | 47 |
| 2 |
|
US Poggibonsi | 20 | 14 | 4 | 2 | 33:11 | 22 | 46 |
| 3 |
|
Follonica Gavorrano | 20 | 10 | 8 | 2 | 33:16 | 17 | 38 |
| 4 |
|
US Arezzo | 20 | 9 | 7 | 4 | 36:29 | 7 | 34 |
| 5 |
|
SC Trestina | 20 | 9 | 6 | 5 | 27:17 | 10 | 33 |
| 6 |
|
Badesse Calcio | 20 | 8 | 6 | 6 | 27:28 | -1 | 30 |
| 7 |
|
US Pianese | 20 | 7 | 7 | 6 | 31:29 | 2 | 28 |
| 8 |
|
Virtus Flaminia | 20 | 7 | 6 | 7 | 35:34 | 1 | 27 |
| 9 |
|
SSD Tiferno Lerchi | 20 | 6 | 9 | 5 | 26:28 | -2 | 27 |
| 10 |
|
Montespaccato | 20 | 7 | 5 | 8 | 29:26 | 3 | 26 |
| 11 |
|
AC Sangiovannese | 20 | 6 | 7 | 7 | 28:28 | 0 | 25 |
| 12 |
|
Scandicci Calcio | 20 | 7 | 4 | 9 | 20:27 | -7 | 25 |
| 13 |
|
Foligno Calcio | 20 | 6 | 6 | 8 | 31:37 | -6 | 24 |
| 14 |
|
Unipomezia Virtus | 20 | 5 | 5 | 10 | 24:40 | -16 | 20 |
| 15 |
|
ASD Cannara | 20 | 4 | 5 | 11 | 16:27 | -11 | 17 |
| 16 |
|
FC Rieti | 20 | 4 | 5 | 11 | 21:38 | -17 | 17 |
| 17 |
|
Cascina | 20 | 3 | 5 | 12 | 18:30 | -12 | 14 |
| 18 |
|
Pro Livorno Sorgenti | 20 | 3 | 3 | 14 | 21:47 | -26 | 12 |
| Promotion | |
| Play-off | |
| Relégation | |
| Relégation |
