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| H (Match allé) | Santa Lucía | - | Comunicaciones | 0:3 (0:0) | ||
| R (match retour) | Comunicaciones | - | Santa Lucía | 0:0 (0:0) | ||
| H (Match allé): 11.05.2022 19:00 | R (match retour): 15.05.2022 02:00 | vainqueur: Comunicaciones | ||||
| H (Match allé) | Achuapa | - | CSD Municipal | 0:1 (0:1) | ||
| R (match retour) | CSD Municipal | - | Achuapa | 2:0 (0:0) | ||
| H (Match allé): 11.05.2022 23:00 | R (match retour): 14.05.2022 23:00 | vainqueur: CSD Municipal | ||||
| H (Match allé) | Cobán Imperial | - | Deportivo Malacateco | 0:0 (0:0) | ||
| R (match retour) | Deportivo Malacateco | - | Cobán Imperial | 0:0 (0:0) | ||
| H (Match allé): 12.05.2022 23:00 | R (match retour): 15.05.2022 21:00 | |||||
| H (Match allé) | Antigua GFC | - | Deportivo Guastatoya | 1:0 (1:0) | ||
| R (match retour) | Deportivo Guastatoya | - | Antigua GFC | 2:0 (1:0) | ||
| H (Match allé): 13.05.2022 03:00 | R (match retour): 15.05.2022 18:45 | vainqueur: Deportivo Guastatoya | ||||
