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| 09.10.2021 | 18:00 | AS Poissy | - | FC Lorient (CFA) | 1:2 (1:1) | |
| 18:00 | C'Chartres Football | - | Blois Foot 41 | 3:1 (1:1) | ||
| 18:00 | EA Guingamp (CFA) | - | SM Caen (CFA) | 1:1 (1:0) | ||
| 18:00 | US Granvillaise | - | US Saint-Malo | 1:0 (1:0) | ||
| 18:00 | FC Rouen 1899 | - | AS Vitré | 1:1 (0:1) | ||
| 18:00 | SO Romorantin | - | FC Versailles | 1:3 (1:0) | ||
| 18:00 | Châteaubriant Voltigeurs | - | St-Pryvé St-Hilaire | 0:1 (0:1) | ||
| 18:30 | Vannes OC | - | Stade Plabennec | 1:1 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Lorient (CFA) | 9 | 6 | 2 | 1 | 15:5 | 10 | 20 |
| 2 |
|
FC Versailles | 9 | 4 | 5 | 0 | 13:5 | 8 | 17 |
| 3 |
|
C'Chartres Football | 9 | 5 | 1 | 3 | 14:9 | 5 | 16 |
| 4 |
|
St-Pryvé St-Hilaire | 9 | 5 | 1 | 3 | 10:7 | 3 | 16 |
| 5 |
|
Blois Foot 41 | 9 | 5 | 1 | 3 | 12:14 | -2 | 16 |
| 6 |
|
Châteaubriant Voltigeurs | 9 | 4 | 2 | 3 | 12:8 | 4 | 14 |
| 7 |
|
FC Rouen 1899 | 9 | 3 | 4 | 2 | 11:9 | 2 | 13 |
| 8 |
|
Vannes OC | 9 | 3 | 4 | 2 | 10:8 | 2 | 13 |
| 9 |
|
EA Guingamp (CFA) | 9 | 3 | 3 | 3 | 12:12 | 0 | 12 |
| 10 |
|
AS Poissy | 9 | 2 | 5 | 2 | 9:6 | 3 | 11 |
| 11 |
|
US Granvillaise | 9 | 2 | 5 | 2 | 7:6 | 1 | 11 |
| 12 |
|
SM Caen (CFA) | 9 | 2 | 4 | 3 | 7:11 | -4 | 10 |
| 13 |
|
SO Romorantin | 9 | 2 | 3 | 4 | 9:14 | -5 | 9 |
| 14 |
|
Stade Plabennec | 9 | 1 | 3 | 5 | 5:11 | -6 | 6 |
| 15 |
|
US Saint-Malo | 9 | 1 | 2 | 6 | 6:16 | -10 | 5 |
| 16 |
|
AS Vitré | 9 | 0 | 3 | 6 | 3:14 | -11 | 3 |
| Promotion | |
| Relégation |
