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| 06.11.2021 | 15:00 | AJ Auxerre | - | Pau FC | 4:1 (1:0) | |
| 15:00 | FC Sochaux | - | Nîmes Olympique | 0:1 (0:0) | ||
| 19:00 | AC Ajaccio | - | Dijon FCO | 1:0 (0:0) | ||
| 19:00 | Havre AC | - | Valenciennes FC | 0:0 (0:0) | ||
| 19:00 | EA Guingamp | - | SC Bastia | 2:3 (0:1) | ||
| 19:00 | Chamois Niortais | - | AS Nancy Lorraine | 1:3 (0:1) | ||
| 19:00 | Paris FC | - | Rodez AF | 1:0 (1:0) | ||
| 19:00 | Grenoble Foot 38 | - | USL Dunkerque | 1:0 (0:0) | ||
| 19:00 | Amiens SC | - | SM Caen | 0:0 (0:0) | ||
| 19:00 | US Quevilly-Rouen | - | Toulouse FC | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Toulouse FC | 15 | 8 | 6 | 1 | 32:13 | 19 | 30 |
| 2 |
|
AJ Auxerre | 15 | 8 | 5 | 2 | 25:15 | 10 | 29 |
| 3 |
|
AC Ajaccio | 15 | 8 | 4 | 3 | 17:8 | 9 | 28 |
| 4 |
|
FC Sochaux | 15 | 8 | 4 | 3 | 14:8 | 6 | 28 |
| 5 |
|
Havre AC | 15 | 6 | 7 | 2 | 14:8 | 6 | 25 |
| 6 |
|
Paris FC | 15 | 7 | 3 | 5 | 18:15 | 3 | 24 |
| 7 |
|
Chamois Niortais | 15 | 6 | 3 | 6 | 16:16 | 0 | 21 |
| 8 |
|
Pau FC | 15 | 6 | 3 | 6 | 15:16 | -1 | 21 |
| 9 |
|
Grenoble Foot 38 | 15 | 6 | 3 | 6 | 15:18 | -3 | 21 |
| 10 |
|
Rodez AF | 15 | 5 | 4 | 6 | 16:16 | 0 | 19 |
| 11 |
|
EA Guingamp | 15 | 4 | 6 | 5 | 18:20 | -2 | 18 |
| 12 |
|
SM Caen | 15 | 4 | 5 | 6 | 16:16 | 0 | 17 |
| 13 |
|
Nîmes Olympique | 15 | 4 | 5 | 6 | 17:19 | -2 | 17 |
| 14 |
|
US Quevilly-Rouen | 15 | 4 | 5 | 6 | 13:19 | -6 | 17 |
| 15 |
|
USL Dunkerque | 15 | 4 | 4 | 7 | 14:18 | -4 | 16 |
| 16 |
|
Dijon FCO | 15 | 5 | 1 | 9 | 14:21 | -7 | 16 |
| 17 |
|
Valenciennes FC | 15 | 4 | 4 | 7 | 12:22 | -10 | 16 |
| 18 |
|
SC Bastia | 15 | 3 | 6 | 6 | 12:16 | -4 | 15 |
| 19 |
|
Amiens SC | 15 | 2 | 8 | 5 | 14:16 | -2 | 14 |
| 20 |
|
AS Nancy Lorraine | 15 | 2 | 6 | 7 | 12:24 | -12 | 12 |
| Promotion | |
| Play-off | |
| Relégation | |
| Relégation |
