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| 21.04.2021 | 19:00 | Levante UD | - | Sevilla FC | 0:1 (0:0) | |
| 19:00 | CA Osasuna | - | Valencia CF | 3:1 (2:1) | ||
| 20:00 | Real Betis | - | Athletic Bilbao | 0:0 (0:0) | ||
| 21:00 | CD Alavés | - | Villarreal CF | 2:1 (1:0) | ||
| 21:00 | Elche CF | - | Real Valladolid | 1:1 (1:0) | ||
| 22:00 | Cádiz CF | - | Real Madrid | 0:3 (0:3) | ||
| 22.04.2021 | 19:00 | Atlético Madrid | - | SD Huesca | 2:0 (1:0) | |
| 21:00 | Granada CF | - | SD Eibar | 4:1 (2:0) | ||
| 21:00 | Real Sociedad | - | RC Celta | 2:1 (2:1) | ||
| 22:00 | FC Barcelona | - | Getafe CF | 5:2 (3:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Madrid | 31 | 21 | 7 | 3 | 54:20 | 34 | 70 |
| 2 |
|
Real Madrid | 31 | 21 | 6 | 4 | 56:24 | 32 | 69 |
| 3 |
|
FC Barcelona | 31 | 21 | 5 | 5 | 74:28 | 46 | 68 |
| 4 |
|
Sevilla FC | 31 | 20 | 4 | 7 | 45:24 | 21 | 64 |
| 5 |
|
Real Sociedad | 31 | 13 | 11 | 7 | 49:32 | 17 | 50 |
| 6 |
|
Real Betis | 31 | 14 | 6 | 11 | 40:43 | -3 | 48 |
| 7 |
|
Villarreal CF | 31 | 11 | 13 | 7 | 44:35 | 9 | 46 |
| 8 |
|
Granada CF | 31 | 12 | 6 | 13 | 40:51 | -11 | 42 |
| 9 |
|
Levante UD | 31 | 9 | 11 | 11 | 37:40 | -3 | 38 |
| 10 |
|
Athletic Bilbao | 31 | 9 | 11 | 11 | 39:33 | 6 | 38 |
| 11 |
|
RC Celta | 31 | 9 | 10 | 12 | 42:50 | -8 | 37 |
| 12 |
|
CA Osasuna | 31 | 9 | 10 | 12 | 28:37 | -9 | 37 |
| 13 |
|
Cádiz CF | 31 | 9 | 8 | 14 | 27:48 | -21 | 35 |
| 14 |
|
Valencia CF | 31 | 8 | 10 | 13 | 38:45 | -7 | 34 |
| 15 |
|
Getafe CF | 31 | 7 | 9 | 15 | 24:39 | -15 | 30 |
| 16 |
|
Real Valladolid | 31 | 5 | 13 | 13 | 28:42 | -14 | 28 |
| 17 |
|
SD Huesca | 31 | 5 | 12 | 14 | 31:47 | -16 | 27 |
| 18 |
|
Elche CF | 31 | 5 | 12 | 14 | 28:47 | -19 | 27 |
| 19 |
|
CD Alavés | 31 | 6 | 9 | 16 | 26:48 | -22 | 27 |
| 20 |
|
SD Eibar | 31 | 4 | 11 | 16 | 23:40 | -17 | 23 |
| Champions League | |
| Europa League | |
| Europa League Quali. | |
| Relégation |
