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| 05.02.2021 | 18:00 | Dynamo České Budějovice | - | Baník Ostrava | 1:0 (0:0) | |
| 06.02.2021 | 16:00 | Bohemians Praha 1905 | - | Zbrojovka Brno | 2:1 (2:1) | |
| 16:00 | MFK Karviná | - | SFC Opava | 3:1 (0:0) | ||
| 18:30 | Viktoria Plzeň | - | Slovan Liberec | 0:2 (0:0) | ||
| 07.02.2021 | 14:00 | FK Teplice | - | FK Pardubice | 0:1 (0:0) | |
| 16:00 | 1. FK Příbram | - | Slavia Praha | 3:3 (2:1) | ||
| 18:30 | Sigma Olomouc | - | AC Sparta Praha | 2:3 (1:0) | ||
| 24.02.2021 | 14:00 | FK Jablonec | - | 1. FC Slovácko | 0:3 (0:1) | |
| 16:00 | FC Fastav Zlín | - | FK Mladá Boleslav | 2:1 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Slavia Praha | 18 | 15 | 3 | 0 | 54:11 | 43 | 48 |
| 2 |
|
AC Sparta Praha | 18 | 12 | 2 | 4 | 36:21 | 15 | 38 |
| 3 |
|
FK Jablonec | 18 | 11 | 2 | 5 | 33:22 | 11 | 35 |
| 4 |
|
1. FC Slovácko | 18 | 10 | 4 | 4 | 33:17 | 16 | 34 |
| 5 |
|
Slovan Liberec | 18 | 9 | 4 | 5 | 27:17 | 10 | 31 |
| 6 |
|
Dynamo České Budějovice | 18 | 7 | 7 | 4 | 24:23 | 1 | 28 |
| 7 |
|
FK Pardubice | 18 | 8 | 4 | 6 | 17:19 | -2 | 28 |
| 8 |
|
Viktoria Plzeň | 18 | 8 | 3 | 7 | 32:23 | 9 | 27 |
| 9 |
|
Sigma Olomouc | 18 | 6 | 8 | 4 | 28:23 | 5 | 26 |
| 10 |
|
Baník Ostrava | 18 | 7 | 5 | 6 | 21:16 | 5 | 26 |
| 11 |
|
MFK Karviná | 18 | 6 | 6 | 6 | 20:26 | -6 | 24 |
| 12 |
|
Bohemians Praha 1905 | 18 | 6 | 4 | 8 | 21:23 | -2 | 22 |
| 13 |
|
FC Fastav Zlín | 18 | 6 | 3 | 9 | 20:26 | -6 | 21 |
| 14 |
|
FK Teplice | 18 | 5 | 2 | 11 | 18:38 | -20 | 17 |
| 15 |
|
Zbrojovka Brno | 18 | 3 | 4 | 11 | 16:33 | -17 | 13 |
| 16 |
|
FK Mladá Boleslav | 18 | 2 | 5 | 11 | 19:33 | -14 | 11 |
| 17 |
|
1. FK Příbram | 18 | 2 | 5 | 11 | 15:36 | -21 | 11 |
| 18 |
|
SFC Opava | 18 | 1 | 5 | 12 | 12:39 | -27 | 8 |
| Champions League Quali. | |
| Europa League Quali. | |
| Relégation |
