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| H (Match allé) | Karmiotissa Polemidion | - | Anorthosis Famagusta | 1:2 (0:1) | ||
| R (match retour) | Anorthosis Famagusta | - | Karmiotissa Polemidion | 5:1 (3:0) | ||
| H (Match allé): 24.02.2021 15:00 | R (match retour): 10.03.2021 17:00 | vainqueur: Anorthosis Famagusta | ||||
| H (Match allé) | APOEL Nikosia | - | Omonia Nikosia | 1:1 (0:0) | ||
| R (match retour) | Omonia Nikosia | - | APOEL Nikosia | 0:1 (0:0) | ||
| H (Match allé): 24.02.2021 17:30 | R (match retour): 10.03.2021 15:00 | vainqueur: APOEL Nikosia | ||||
| H (Match allé) | AEL Limassol | - | Nea Salamina | 2:0 (0:0) | ||
| R (match retour) | Nea Salamina | - | AEL Limassol | 1:0 (0:0) | ||
| H (Match allé): 03.03.2021 16:00 | R (match retour): 17.03.2021 17:00 | vainqueur: AEL Limassol | ||||
| H (Match allé) | Ethnikos Achna | - | Olympiakos Nikosia | 1:1 (0:1) | ||
| R (match retour) | Olympiakos Nikosia | - | Ethnikos Achna | 1:0 (0:0) | ||
| H (Match allé): 03.03.2021 18:00 | R (match retour): 17.03.2021 15:00 | vainqueur: Olympiakos Nikosia | ||||
