 |
 |
|
|
| H (Match allé) | Rosario Central | - | Red Bull Bragantino | 3:4 (1:3) | ||
| R (match retour) | Red Bull Bragantino | - | Rosario Central | 1:0 (0:0) | ||
| H (Match allé): 11.08.2021 00:15 | R (match retour): 18.08.2021 00:15 | vainqueur: Red Bull Bragantino | ||||
| H (Match allé) | Sporting Cristal | - | Peñarol | 1:3 (0:2) | ||
| R (match retour) | Peñarol | - | Sporting Cristal | 1:0 (1:0) | ||
| H (Match allé): 12.08.2021 00:15 | R (match retour): 19.08.2021 00:15 | vainqueur: Peñarol | ||||
| H (Match allé) | LDU Quito | - | Athletico Paranaense | 1:0 (0:0) | ||
| R (match retour) | Athletico Paranaense | - | LDU Quito | 4:2 (2:2) | ||
| H (Match allé): 13.08.2021 00:15 | R (match retour): 20.08.2021 00:15 | vainqueur: Athletico Paranaense | ||||
| H (Match allé) | Santos FC | - | Libertad | 2:1 (1:0) | ||
| R (match retour) | Libertad | - | Santos FC | 1:0 (1:0) | ||
| H (Match allé): 13.08.2021 02:30 | R (match retour): 20.08.2021 02:30 | vainqueur: Libertad | ||||
