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| H (Match allé) | Boca Juniors | - | Atlético Mineiro | 0:0 (0:0) | ||
| R (match retour) | Atlético Mineiro | - | Boca Juniors | 3:1 (0:0, 0:0) tab | ||
| H (Match allé): 14.07.2021 00:15 | R (match retour): 21.07.2021 00:15 | vainqueur: Atlético Mineiro | ||||
| H (Match allé) | Cerro Porteño | - | Fluminense RJ | 0:2 (0:0) | ||
| R (match retour) | Fluminense RJ | - | Cerro Porteño | 1:0 (1:0) | ||
| H (Match allé): 14.07.2021 00:15 | R (match retour): 04.08.2021 00:15 | vainqueur: Fluminense RJ | ||||
| H (Match allé) | São Paulo FC | - | Racing Club | 1:1 (1:1) | ||
| R (match retour) | Racing Club | - | São Paulo FC | 1:3 (0:1) | ||
| H (Match allé): 14.07.2021 02:30 | R (match retour): 21.07.2021 02:30 | vainqueur: São Paulo FC | ||||
| H (Match allé) | Universidad Católica | - | Palmeiras | 0:1 (0:1) | ||
| R (match retour) | Palmeiras | - | Universidad Católica | 1:0 (1:0) | ||
| H (Match allé): 15.07.2021 00:15 | R (match retour): 22.07.2021 00:15 | vainqueur: Palmeiras | ||||
| H (Match allé) | Vélez Sarsfield | - | Barcelona | 1:0 (1:0) | ||
| R (match retour) | Barcelona | - | Vélez Sarsfield | 3:1 (1:0) | ||
| H (Match allé): 15.07.2021 00:15 | R (match retour): 22.07.2021 00:15 | vainqueur: Barcelona | ||||
| H (Match allé) | Defensa y Justicia | - | Flamengo RJ | 0:1 (0:1) | ||
| R (match retour) | Flamengo RJ | - | Defensa y Justicia | 4:1 (1:1) | ||
| H (Match allé): 15.07.2021 02:30 | R (match retour): 22.07.2021 02:30 | vainqueur: Flamengo RJ | ||||
| H (Match allé) | River Plate | - | Argentinos Juniors | 1:1 (1:1) | ||
| R (match retour) | Argentinos Juniors | - | River Plate | 0:2 (0:1) | ||
| H (Match allé): 15.07.2021 02:30 | R (match retour): 22.07.2021 02:30 | vainqueur: River Plate | ||||
| H (Match allé) | Club Olimpia | - | Internacional | 0:0 (0:0) | ||
| R (match retour) | Internacional | - | Club Olimpia | 4:5 (0:0, 0:0) tab | ||
| H (Match allé): 16.07.2021 02:30 | R (match retour): 23.07.2021 02:30 | vainqueur: Club Olimpia | ||||
