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| 27.08.2021 | 20:30 | Borussia Dortmund | - | 1899 Hoffenheim | 3:2 (0:0) | |
| 28.08.2021 | 15:30 | VfB Stuttgart | - | SC Freiburg | 2:3 (2:3) | |
| 15:30 | 1. FSV Mainz 05 | - | SpVgg Greuther Fürth | 3:0 (2:0) | ||
| 15:30 | FC Augsburg | - | Bayer Leverkusen | 1:4 (1:2) | ||
| 15:30 | Arminia Bielefeld | - | Eintracht Frankfurt | 1:1 (0:1) | ||
| 15:30 | 1. FC Köln | - | VfL Bochum | 2:1 (0:0) | ||
| 18:30 | Bayern München | - | Hertha BSC | 5:0 (2:0) | ||
| 29.08.2021 | 15:30 | 1. FC Union Berlin | - | Bor. Mönchengladbach | 2:1 (2:0) | |
| 17:30 | VfL Wolfsburg | - | RB Leipzig | 1:0 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfL Wolfsburg | 3 | 3 | 0 | 0 | 4:1 | 3 | 9 |
| 2 |
|
Bayer Leverkusen | 3 | 2 | 1 | 0 | 9:2 | 7 | 7 |
| 3 |
|
Bayern München | 3 | 2 | 1 | 0 | 9:3 | 6 | 7 |
| 4 |
|
SC Freiburg | 3 | 2 | 1 | 0 | 5:3 | 2 | 7 |
| 5 |
|
Borussia Dortmund | 3 | 2 | 0 | 1 | 9:6 | 3 | 6 |
| 6 |
|
1. FC Köln | 3 | 2 | 0 | 1 | 7:5 | 2 | 6 |
| 7 |
|
1. FSV Mainz 05 | 3 | 2 | 0 | 1 | 4:2 | 2 | 6 |
| 8 |
|
1. FC Union Berlin | 3 | 1 | 2 | 0 | 5:4 | 1 | 5 |
| 9 |
|
1899 Hoffenheim | 3 | 1 | 1 | 1 | 8:5 | 3 | 4 |
| 10 |
|
RB Leipzig | 3 | 1 | 0 | 2 | 4:2 | 2 | 3 |
| 11 |
|
VfL Bochum | 3 | 1 | 0 | 2 | 3:3 | 0 | 3 |
| 12 |
|
Arminia Bielefeld | 3 | 0 | 3 | 0 | 2:2 | 0 | 3 |
| 13 |
|
VfB Stuttgart | 3 | 1 | 0 | 2 | 7:8 | -1 | 3 |
| 14 |
|
Eintracht Frankfurt | 3 | 0 | 2 | 1 | 3:6 | -3 | 2 |
| 15 |
|
Bor. Mönchengladbach | 3 | 0 | 1 | 2 | 2:7 | -5 | 1 |
| 16 |
|
SpVgg Greuther Fürth | 3 | 0 | 1 | 2 | 2:9 | -7 | 1 |
| 17 |
|
FC Augsburg | 3 | 0 | 1 | 2 | 1:8 | -7 | 1 |
| 18 |
|
Hertha BSC | 3 | 0 | 0 | 3 | 2:10 | -8 | 0 |
| Champions League | |
| Europa League | |
| Relégation | |
| Relégation |
