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| 03.12.2021 | 20:30 | 1. FC Union Berlin | - | RB Leipzig | 2:1 (1:1) | |
| 04.12.2021 | 15:30 | Bayer Leverkusen | - | SpVgg Greuther Fürth | 7:1 (3:1) | |
| 15:30 | 1899 Hoffenheim | - | Eintracht Frankfurt | 3:2 (2:1) | ||
| 15:30 | 1. FSV Mainz 05 | - | VfL Wolfsburg | 3:0 (2:0) | ||
| 15:30 | FC Augsburg | - | VfL Bochum | 2:3 (0:3) | ||
| 15:30 | Arminia Bielefeld | - | 1. FC Köln | 1:1 (0:1) | ||
| 18:30 | Borussia Dortmund | - | Bayern München | 2:3 (1:2) | ||
| 05.12.2021 | 15:30 | VfB Stuttgart | - | Hertha BSC | 2:2 (2:1) | |
| 17:30 | Bor. Mönchengladbach | - | SC Freiburg | 0:6 (0:6) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 14 | 11 | 1 | 2 | 45:15 | 30 | 34 |
| 2 |
|
Borussia Dortmund | 14 | 10 | 0 | 4 | 35:22 | 13 | 30 |
| 3 |
|
Bayer Leverkusen | 14 | 8 | 3 | 3 | 35:19 | 16 | 27 |
| 4 |
|
SC Freiburg | 14 | 7 | 4 | 3 | 25:13 | 12 | 25 |
| 5 |
|
1899 Hoffenheim | 14 | 7 | 2 | 5 | 30:22 | 8 | 23 |
| 6 |
|
1. FC Union Berlin | 14 | 6 | 5 | 3 | 22:20 | 2 | 23 |
| 7 |
|
1. FSV Mainz 05 | 14 | 6 | 3 | 5 | 20:14 | 6 | 21 |
| 8 |
|
VfL Wolfsburg | 14 | 6 | 2 | 6 | 15:20 | -5 | 20 |
| 9 |
|
1. FC Köln | 14 | 4 | 7 | 3 | 23:23 | 0 | 19 |
| 10 |
|
VfL Bochum | 14 | 6 | 1 | 7 | 15:22 | -7 | 19 |
| 11 |
|
RB Leipzig | 14 | 5 | 3 | 6 | 25:18 | 7 | 18 |
| 12 |
|
Eintracht Frankfurt | 14 | 4 | 6 | 4 | 18:20 | -2 | 18 |
| 13 |
|
Bor. Mönchengladbach | 14 | 5 | 3 | 6 | 18:24 | -6 | 18 |
| 14 |
|
Hertha BSC | 14 | 4 | 3 | 7 | 15:29 | -14 | 15 |
| 15 |
|
VfB Stuttgart | 14 | 3 | 5 | 6 | 20:25 | -5 | 14 |
| 16 |
|
FC Augsburg | 14 | 3 | 4 | 7 | 14:25 | -11 | 13 |
| 17 |
|
Arminia Bielefeld | 14 | 1 | 7 | 6 | 10:20 | -10 | 10 |
| 18 |
|
SpVgg Greuther Fürth | 14 | 0 | 1 | 13 | 12:46 | -34 | 1 |
| Champions League | |
| Europa League | |
| Relégation | |
| Relégation |
