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| H (Match allé) | Athletico Paranaense | - | Santos FC | 1:0 (1:0) | ||
| R (match retour) | Santos FC | - | Athletico Paranaense | 0:1 (0:0) | ||
| H (Match allé): 26.08.2021 00:00 | R (match retour): 15.09.2021 02:30 | vainqueur: Athletico Paranaense | ||||
| H (Match allé) | São Paulo FC | - | Fortaleza | 2:2 (0:0) | ||
| R (match retour) | Fortaleza | - | São Paulo FC | 3:1 (1:0) | ||
| H (Match allé): 26.08.2021 02:30 | R (match retour): 16.09.2021 02:30 | vainqueur: Fortaleza | ||||
| H (Match allé) | Grêmio Porto Alegre | - | Flamengo RJ | 0:4 (0:0) | ||
| R (match retour) | Flamengo RJ | - | Grêmio Porto Alegre | 2:0 (0:0) | ||
| H (Match allé): 26.08.2021 02:30 | R (match retour): 16.09.2021 02:30 | vainqueur: Flamengo RJ | ||||
| H (Match allé) | Fluminense RJ | - | Atlético Mineiro | 1:2 (1:2) | ||
| R (match retour) | Atlético Mineiro | - | Fluminense RJ | 1:0 (0:0) | ||
| H (Match allé): 27.08.2021 02:30 | R (match retour): 16.09.2021 00:00 | vainqueur: Atlético Mineiro | ||||
