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| H (Match allé) | Atlético Mineiro | - | Fortaleza | 4:0 (3:0) | ||
| R (match retour) | Fortaleza | - | Atlético Mineiro | 1:2 (0:0) | ||
| H (Match allé): 21.10.2021 02:30 | R (match retour): 28.10.2021 02:30 | vainqueur: Atlético Mineiro | ||||
| H (Match allé) | Athletico Paranaense | - | Flamengo RJ | 2:2 (0:1) | ||
| R (match retour) | Flamengo RJ | - | Athletico Paranaense | 0:3 (0:2) | ||
| H (Match allé): 21.10.2021 02:30 | R (match retour): 28.10.2021 02:30 | vainqueur: Athletico Paranaense | ||||
