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| H (Match allé) | Hercílio Luz - SC | - | Chapecoense | ann. | ||
| R (match retour) | Chapecoense | - | Hercílio Luz - SC | ann. | ||
| H (Match allé): 25.04.2021 21:00 | R (match retour): 29.04.2021 02:30 | |||||
| H (Match allé) | Joinville - SC | - | Brusque - SC | 2:2 (2:1) | ||
| R (match retour) | Brusque - SC | - | Joinville - SC | 1:0 (0:0) | ||
| H (Match allé): 25.04.2021 21:00 | R (match retour): 29.04.2021 00:00 | vainqueur: Brusque - SC | ||||
| H (Match allé) | Marcílio Dias - SC | - | Juventus - SC | 1:0 (1:0) | ||
| R (match retour) | Juventus - SC | - | Marcílio Dias - SC | 0:1 (0:0) | ||
| H (Match allé): 26.04.2021 00:00 | R (match retour): 29.04.2021 00:00 | vainqueur: Marcílio Dias - SC | ||||
| H (Match allé) | Próspera - SC | - | Avaí - SC | 0:1 (0:0) | ||
| R (match retour) | Avaí - SC | - | Próspera - SC | 2:1 (1:0) | ||
| H (Match allé): 26.04.2021 00:00 | R (match retour): 29.04.2021 01:30 | vainqueur: Avaí - SC | ||||
| H (Match allé) | Figueirense - SC | - | Chapecoense | 3:1 (3:0) | ||
| R (match retour) | Chapecoense | - | Figueirense - SC | 2:0 (1:0) | ||
| H (Match allé): 09.05.2021 21:00 | R (match retour): 13.05.2021 01:30 | vainqueur: Chapecoense | ||||
