 |
 |
|
|
| 21.01.2022 | 20:45 | KV Oostende | - | Royal Antwerp FC | 1:2 (0:0) | |
| 22.01.2022 | 16:15 | KV Kortrijk | - | KAS Eupen | 1:1 (0:1) | |
| 18:30 | K Beerschot VA | - | Oud-Heverlee Leuven | 3:1 (2:1) | ||
| 18:30 | Sint-Truidense VV | - | RFC Seraing | 3:1 (1:1) | ||
| 20:45 | Sporting Charleroi | - | KAA Gent | 0:0 (0:0) | ||
| 23.01.2022 | 13:30 | Standard Liège | - | Club Brugge KV | 2:2 (1:1) | |
| 16:00 | Union Saint-Gilloise | - | KRC Genk | 2:1 (1:0) | ||
| 18:30 | KV Mechelen | - | RSC Anderlecht | 0:1 (0:1) | ||
| 21:00 | Cercle Brugge | - | SV Zulte Waregem | 3:1 (2:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Union Saint-Gilloise | 23 | 17 | 2 | 4 | 56:21 | 35 | 53 |
| 2 |
|
Royal Antwerp FC | 23 | 14 | 4 | 5 | 44:25 | 19 | 46 |
| 3 |
|
Club Brugge KV | 23 | 12 | 8 | 3 | 45:30 | 15 | 44 |
| 4 |
|
RSC Anderlecht | 23 | 11 | 9 | 3 | 52:27 | 25 | 42 |
| 5 |
|
KAA Gent | 23 | 10 | 6 | 7 | 35:24 | 11 | 36 |
| 6 |
|
Sporting Charleroi | 23 | 10 | 6 | 7 | 38:32 | 6 | 36 |
| 7 |
|
KV Kortrijk | 23 | 8 | 9 | 6 | 29:27 | 2 | 33 |
| 8 |
|
KV Mechelen | 23 | 10 | 3 | 10 | 37:43 | -6 | 33 |
| 9 |
|
KRC Genk | 23 | 9 | 5 | 9 | 45:36 | 9 | 32 |
| 10 |
|
Cercle Brugge | 23 | 9 | 4 | 10 | 33:29 | 4 | 31 |
| 11 |
|
Oud-Heverlee Leuven | 23 | 7 | 8 | 8 | 35:37 | -2 | 29 |
| 12 |
|
Standard Liège | 23 | 7 | 7 | 9 | 26:37 | -11 | 28 |
| 13 |
|
Sint-Truidense VV | 23 | 8 | 3 | 12 | 25:34 | -9 | 27 |
| 14 |
|
KAS Eupen | 23 | 7 | 5 | 11 | 31:39 | -8 | 26 |
| 15 |
|
SV Zulte Waregem | 23 | 6 | 6 | 11 | 32:48 | -16 | 24 |
| 16 |
|
KV Oostende | 23 | 7 | 3 | 13 | 24:45 | -21 | 24 |
| 17 |
|
RFC Seraing | 23 | 6 | 1 | 16 | 24:49 | -25 | 19 |
| 18 |
|
K Beerschot VA | 23 | 3 | 3 | 17 | 19:47 | -28 | 12 |
| Play-off | |
| Play-off | |
| Relégation | |
| Relégation |
