 |
 |
|
|
| 26.12.2021 | 13:30 | Cercle Brugge | - | Club Brugge KV | 2:0 (0:0) | |
| 16:00 | Standard Liège | - | SV Zulte Waregem | 0:1 (0:0) | ||
| 18:30 | Union Saint-Gilloise | - | KAA Gent | 0:0 (0:0) | ||
| 21:00 | KV Oostende | - | KRC Genk | 0:4 (0:3) | ||
| 27.12.2021 | 18:45 | KV Mechelen | - | RFC Seraing | 2:0 (0:0) | |
| 18:45 | Sporting Charleroi | - | Oud-Heverlee Leuven | 0:3 (0:1) | ||
| 21:00 | K Beerschot VA | - | RSC Anderlecht | 0:7 (0:3) | ||
| 21:00 | Sint-Truidense VV | - | KAS Eupen | 2:0 (1:0) | ||
| 02.02.2022 | 18:45 | KV Kortrijk | - | Royal Antwerp FC | 0:2 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Union Saint-Gilloise | 21 | 15 | 2 | 4 | 50:20 | 30 | 47 |
| 2 |
|
Royal Antwerp FC | 21 | 12 | 4 | 5 | 39:24 | 15 | 40 |
| 3 |
|
Club Brugge KV | 21 | 11 | 7 | 3 | 41:28 | 13 | 40 |
| 4 |
|
RSC Anderlecht | 21 | 10 | 8 | 3 | 50:26 | 24 | 38 |
| 5 |
|
Sporting Charleroi | 21 | 10 | 5 | 6 | 38:29 | 9 | 35 |
| 6 |
|
KAA Gent | 21 | 10 | 4 | 7 | 33:22 | 11 | 34 |
| 7 |
|
KV Mechelen | 21 | 10 | 3 | 8 | 37:37 | 0 | 33 |
| 8 |
|
KV Kortrijk | 21 | 8 | 7 | 6 | 26:24 | 2 | 31 |
| 9 |
|
KRC Genk | 21 | 8 | 5 | 8 | 40:33 | 7 | 29 |
| 10 |
|
Oud-Heverlee Leuven | 21 | 6 | 8 | 7 | 29:34 | -5 | 26 |
| 11 |
|
Standard Liège | 21 | 7 | 5 | 9 | 23:34 | -11 | 26 |
| 12 |
|
Cercle Brugge | 21 | 7 | 4 | 10 | 28:28 | 0 | 25 |
| 13 |
|
KAS Eupen | 21 | 7 | 4 | 10 | 30:36 | -6 | 25 |
| 14 |
|
Sint-Truidense VV | 21 | 7 | 3 | 11 | 22:31 | -9 | 24 |
| 15 |
|
SV Zulte Waregem | 21 | 6 | 5 | 10 | 31:45 | -14 | 23 |
| 16 |
|
KV Oostende | 21 | 7 | 2 | 12 | 23:43 | -20 | 23 |
| 17 |
|
RFC Seraing | 21 | 6 | 1 | 14 | 23:42 | -19 | 19 |
| 18 |
|
K Beerschot VA | 21 | 2 | 3 | 16 | 15:42 | -27 | 9 |
| Play-off | |
| Play-off | |
| Relégation | |
| Relégation |
