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| 05.11.2022 | 11:00 | FC Schalke 04 | - | Sportfreunde Siegen | 5:0 (3:0) | |
| 11:00 | FC Hennef 05 | - | Bayer Leverkusen | 1:5 (1:1) | ||
| 11:00 | Rot-Weiss Essen | - | SV Deutz 05 | 5:0 (3:0) | ||
| 11:00 | Bor. Mönchengladbach | - | Borussia Dortmund | 1:0 (0:0) | ||
| 12:00 | Preußen Münster | - | MSV Duisburg | 1:1 (0:1) | ||
| 13:00 | Arminia Bielefeld | - | Fortuna Düsseldorf | 5:1 (2:1) | ||
| 13:00 | Fortuna Köln | - | 1. FC Köln | 2:5 (2:3) | ||
| 13:00 | SC Paderborn 07 | - | VfL Bochum | 1:1 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Schalke 04 | 10 | 9 | 1 | 0 | 31:2 | 29 | 28 |
| 2 |
|
Arminia Bielefeld | 10 | 8 | 2 | 0 | 39:13 | 26 | 26 |
| 3 |
|
1. FC Köln | 10 | 8 | 1 | 1 | 37:15 | 22 | 25 |
| 4 |
|
Borussia Dortmund | 10 | 6 | 2 | 2 | 35:10 | 25 | 20 |
| 5 |
|
Bayer Leverkusen | 10 | 6 | 1 | 3 | 31:13 | 18 | 19 |
| 6 |
|
Bor. Mönchengladbach | 10 | 5 | 4 | 1 | 19:12 | 7 | 19 |
| 7 |
|
Fortuna Düsseldorf | 10 | 5 | 2 | 3 | 29:19 | 10 | 17 |
| 8 |
|
VfL Bochum | 10 | 4 | 3 | 3 | 22:17 | 5 | 15 |
| 9 |
|
Rot-Weiss Essen | 10 | 3 | 3 | 4 | 14:17 | -3 | 12 |
| 10 |
|
SC Paderborn 07 | 10 | 2 | 4 | 4 | 14:25 | -11 | 10 |
| 11 |
|
MSV Duisburg | 10 | 3 | 1 | 6 | 13:24 | -11 | 10 |
| 12 |
|
Preußen Münster | 10 | 2 | 3 | 5 | 12:20 | -8 | 9 |
| 13 |
|
Fortuna Köln | 10 | 2 | 1 | 7 | 12:37 | -25 | 7 |
| 14 |
|
FC Hennef 05 | 10 | 1 | 2 | 7 | 9:27 | -18 | 5 |
| 15 |
|
Sportfreunde Siegen | 10 | 1 | 0 | 9 | 7:35 | -28 | 3 |
| 16 |
|
SV Deutz 05 | 10 | 0 | 0 | 10 | 8:46 | -38 | 0 |
| Play-off | |
| Relégation |
