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| 15.10.2021 | 19:30 | Godoy Cruz | - | Central Córdoba SdE | 0:0 (0:0) | |
| 21:45 | Rosario Central | - | Patronato de Paraná | 3:2 (1:1) | ||
| 16.10.2021 | 00:00 | Racing Club | - | Platense | 0:1 (0:0) | |
| 02:15 | Defensa y Justicia | - | Estudiantes | 2:1 (1:0) | ||
| 02:15 | Vélez Sarsfield | - | Arsenal de Sarandí | 0:0 (0:0) | ||
| 18:30 | Sarmiento de Junín | - | Unión de Santa Fe | 3:4 (1:1) | ||
| 20:45 | Gimnasia de La Plata | - | Newell's Old Boys | 1:0 (1:0) | ||
| 23:00 | Lanús | - | Banfield | 1:1 (0:1) | ||
| 17.10.2021 | 01:15 | Huracán | - | Boca Juniors | 0:3 (0:1) | |
| 20:45 | Atlético Tucumán | - | Argentinos Juniors | 4:3 (2:0) | ||
| 20:45 | Colón de Santa Fe | - | Talleres de Córdoba | 1:0 (1:0) | ||
| 23:00 | Aldosivi | - | Independiente | 1:0 (1:0) | ||
| 18.10.2021 | 01:15 | River Plate | - | San Lorenzo | 3:1 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate | 16 | 11 | 3 | 2 | 32:12 | 20 | 36 |
| 2 |
|
Talleres de Córdoba | 16 | 10 | 2 | 4 | 24:14 | 10 | 32 |
| 3 |
|
Boca Juniors | 16 | 7 | 6 | 3 | 19:12 | 7 | 27 |
| 4 |
|
Lanús | 16 | 8 | 3 | 5 | 27:25 | 2 | 27 |
| 5 |
|
Estudiantes | 16 | 7 | 5 | 4 | 25:17 | 8 | 26 |
| 6 |
|
Colón de Santa Fe | 16 | 7 | 5 | 4 | 13:16 | -3 | 26 |
| 7 |
|
Vélez Sarsfield | 16 | 6 | 7 | 3 | 22:12 | 10 | 25 |
| 8 |
|
Defensa y Justicia | 16 | 6 | 6 | 4 | 20:13 | 7 | 24 |
| 9 |
|
Independiente | 16 | 6 | 6 | 4 | 17:15 | 2 | 24 |
| 10 |
|
Godoy Cruz | 16 | 6 | 5 | 5 | 25:20 | 5 | 23 |
| 11 |
|
Racing Club | 16 | 5 | 7 | 4 | 13:9 | 4 | 22 |
| 12 |
|
Huracán | 16 | 5 | 7 | 4 | 12:12 | 0 | 22 |
| 13 |
|
Argentinos Juniors | 16 | 5 | 6 | 5 | 15:14 | 1 | 21 |
| 14 |
|
Gimnasia de La Plata | 16 | 5 | 6 | 5 | 13:16 | -3 | 21 |
| 15 |
|
Unión de Santa Fe | 16 | 6 | 3 | 7 | 19:23 | -4 | 21 |
| 16 |
|
Rosario Central | 16 | 6 | 2 | 8 | 23:23 | 0 | 20 |
| 17 |
|
Platense | 16 | 4 | 7 | 5 | 18:19 | -1 | 19 |
| 18 |
|
Sarmiento de Junín | 16 | 5 | 4 | 7 | 18:20 | -2 | 19 |
| 19 |
|
Atlético Tucumán | 16 | 5 | 4 | 7 | 16:23 | -7 | 19 |
| 20 |
|
San Lorenzo | 16 | 4 | 5 | 7 | 14:20 | -6 | 17 |
| 21 |
|
Newell's Old Boys | 16 | 4 | 4 | 8 | 17:24 | -7 | 16 |
| 22 |
|
Aldosivi | 16 | 5 | 1 | 10 | 17:29 | -12 | 16 |
| 23 |
|
Banfield | 16 | 2 | 9 | 5 | 11:15 | -4 | 15 |
| 24 |
|
Patronato de Paraná | 16 | 3 | 6 | 7 | 13:19 | -6 | 15 |
| 25 |
|
Arsenal de Sarandí | 16 | 2 | 7 | 7 | 6:20 | -14 | 13 |
| 26 |
|
Central Córdoba SdE | 16 | 2 | 6 | 8 | 15:22 | -7 | 12 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
