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| 27.05.2022 | 23:00 | Independiente Rivadavia | - | Estudiantes de Caseros | 2:0 (2:0) | |
| 28.05.2022 | 01:10 | Agropecuario Argentino | - | Brown de Adrogué | 1:1 (0:0) | |
| 20:10 | Instituto de Córdoba | - | Chacarita Juniors | 2:0 (2:0) | ||
| 20:10 | Nueva Chicago | - | Chaco For Ever | 1:0 (0:0) | ||
| 20:30 | Flandria | - | Villa Dálmine | 3:1 (3:0) | ||
| 20:30 | Sacachispas | - | Guillermo Brown | 0:0 (0:0) | ||
| 23:00 | Tristan Suárez | - | Defensores de Belgrano | 0:2 (0:1) | ||
| 29.05.2022 | 00:10 | Quilmes | - | Atlanta | 1:3 (0:1) | |
| 20:00 | Deportivo Madryn | - | Güemes de SdE | 0:1 (0:1) | ||
| 20:10 | Estudiantes de Río Cuarto | - | All Boys | 1:1 (0:0) | ||
| 20:30 | Deportivo Maipú | - | San Martín de San Juan | 2:2 (1:0) | ||
| 20:30 | Gimnasia de Jujuy | - | Almirante Brown | 3:0 (1:0) | ||
| 21:00 | Alvarado | - | Gimnasia de Mendoza | 0:0 (0:0) | ||
| 22:00 | Mitre de SdE | - | Atlético Rafaela | 2:2 (1:2) | ||
| 22:10 | Temperley | - | Belgrano de Córdoba | 1:1 (1:1) | ||
| 30.05.2022 | 00:10 | Ferro Carril Oeste | - | Ramón Santamarina | 1:0 (0:0) | |
| 02:10 | Almagro | - | San Telmo | 2:1 (0:1) | ||
| 31.05.2022 | 02:10 | Deportivo Morón | - | Deportivo Riestra | 1:1 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 16 | 12 | 2 | 2 | 22:10 | 12 | 38 |
| 2 |
|
San Martín de Tucumán | 16 | 9 | 5 | 2 | 22:13 | 9 | 32 |
| 3 |
|
Brown de Adrogué | 17 | 8 | 7 | 2 | 24:16 | 8 | 31 |
| 4 |
|
Instituto de Córdoba | 16 | 8 | 6 | 2 | 20:12 | 8 | 30 |
| 5 |
|
Almagro | 17 | 8 | 4 | 5 | 17:17 | 0 | 28 |
| 6 |
|
All Boys | 16 | 6 | 9 | 1 | 21:13 | 8 | 27 |
| 7 |
|
Estudiantes de Caseros | 17 | 7 | 6 | 4 | 16:13 | 3 | 27 |
| 8 |
|
Gimnasia de Mendoza | 16 | 7 | 5 | 4 | 20:10 | 10 | 26 |
| 9 |
|
Chacarita Juniors | 17 | 7 | 5 | 5 | 28:22 | 6 | 26 |
| 10 |
|
Estudiantes de Río Cuarto | 17 | 6 | 7 | 4 | 16:17 | -1 | 25 |
| 11 |
|
Chaco For Ever | 17 | 5 | 9 | 3 | 20:13 | 7 | 24 |
| 12 |
|
Deportivo Madryn | 17 | 6 | 6 | 5 | 23:18 | 5 | 24 |
| 13 |
|
Independiente Rivadavia | 16 | 7 | 3 | 6 | 22:19 | 3 | 24 |
| 14 |
|
Deportivo Maipú | 17 | 5 | 9 | 3 | 15:13 | 2 | 24 |
| 15 |
|
Guillermo Brown | 17 | 7 | 3 | 7 | 16:16 | 0 | 24 |
| 16 |
|
Agropecuario Argentino | 16 | 5 | 8 | 3 | 16:11 | 5 | 23 |
| 17 |
|
San Martín de San Juan | 17 | 6 | 4 | 7 | 22:20 | 2 | 22 |
| 18 |
|
Quilmes | 16 | 5 | 7 | 4 | 21:19 | 2 | 22 |
| 19 |
|
Nueva Chicago | 17 | 5 | 7 | 5 | 19:18 | 1 | 22 |
| 20 |
|
Defensores de Belgrano | 17 | 5 | 7 | 5 | 18:19 | -1 | 22 |
| 21 |
|
Deportivo Riestra | 16 | 4 | 9 | 3 | 12:13 | -1 | 21 |
| 22 |
|
Alvarado | 17 | 5 | 6 | 6 | 17:24 | -7 | 21 |
| 23 |
|
Atlanta | 17 | 4 | 8 | 5 | 18:18 | 0 | 20 |
| 24 |
|
Gimnasia de Jujuy | 17 | 5 | 5 | 7 | 17:23 | -6 | 20 |
| 25 |
|
Almirante Brown | 16 | 4 | 7 | 5 | 18:21 | -3 | 19 |
| 26 |
|
Ferro Carril Oeste | 16 | 4 | 7 | 5 | 15:18 | -3 | 19 |
| 27 |
|
Deportivo Morón | 17 | 3 | 9 | 5 | 10:10 | 0 | 18 |
| 28 |
|
Temperley | 17 | 4 | 5 | 8 | 15:22 | -7 | 17 |
| 29 |
|
Güemes de SdE | 16 | 3 | 7 | 6 | 9:13 | -4 | 16 |
| 30 |
|
Atlético Rafaela | 17 | 3 | 6 | 8 | 16:18 | -2 | 15 |
| 31 |
|
Mitre de SdE | 16 | 3 | 6 | 7 | 17:20 | -3 | 15 |
| 32 |
|
Sacachispas | 16 | 2 | 9 | 5 | 13:16 | -3 | 15 |
| 33 |
|
Flandria | 17 | 3 | 6 | 8 | 20:25 | -5 | 15 |
| 34 |
|
San Telmo | 16 | 3 | 6 | 7 | 16:26 | -10 | 15 |
| 35 |
|
Villa Dálmine | 16 | 2 | 8 | 6 | 18:26 | -8 | 14 |
| 36 |
|
Tristan Suárez | 16 | 1 | 7 | 8 | 15:25 | -10 | 10 |
| 37 |
|
Ramón Santamarina | 17 | 1 | 6 | 10 | 10:27 | -17 | 9 |
| Promotion | |
| Play-off | |
| Play-off | |
| Relégation |
