H (Match allé) KS Besëlidhja Lezhë - KF Apolonia Fier 0:1
R (match retour) KF Apolonia Fier - KS Besëlidhja Lezhë -:-
H (Match allé): 25.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) Flamurtari Vlorë - FK Vllaznia 2:1
R (match retour) FK Vllaznia - Flamurtari Vlorë -:-
H (Match allé): 26.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) KS Pogradeci - KF Bylis Ballsh 0:3
R (match retour) KF Bylis Ballsh - KS Pogradeci -:-
H (Match allé): 26.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) KS Besa - KS Korabi Peshkopi 1:1
R (match retour) KS Korabi Peshkopi - KS Besa -:-
H (Match allé): 26.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) Labëria FC - FK Kukësi 0:3
R (match retour) FK Kukësi - Labëria FC -:-
H (Match allé): 26.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) Luzi United - KF Teuta Durrës 0:0
R (match retour) KF Teuta Durrës - Luzi United -:-
H (Match allé): 26.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) KF Maliqi - KF Skënderbeu 1:5
R (match retour) KF Skënderbeu - KF Maliqi -:-
H (Match allé): 26.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) Turbina Cërrik - Erzeni Shijak 1:2
R (match retour) Erzeni Shijak - Turbina Cërrik -:-
H (Match allé): 26.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) KF Devolli - KF Laçi 0:2
R (match retour) KF Laçi - KF Devolli -:-
H (Match allé): 26.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) KS Kastrioti - FK Vora 1:0
R (match retour) FK Vora - KS Kastrioti -:-
H (Match allé): 26.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) KF Oriku - FK Partizani 0:0
R (match retour) FK Partizani - KF Oriku -:-
H (Match allé): 28.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) Butrinti Sarandë - Dinamo Tiranë 0:1
R (match retour) Dinamo Tiranë - Butrinti Sarandë -:-
H (Match allé): 28.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) KF Lushnja - KF Tërbuni Pukë 2:0
R (match retour) KF Tërbuni Pukë - KF Lushnja -:-
H (Match allé): 28.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) KS Shkumbini - Egnatia Rrogozhine 0:3
R (match retour) Egnatia Rrogozhine - KS Shkumbini -:-
H (Match allé): 28.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) KS Burreli - FK Tomori Berat 2:1
R (match retour) FK Tomori Berat - KS Burreli -:-
H (Match allé): 28.09.2022 15:00 R (match retour): 12.10.2022
H (Match allé) KF Veleçiku Koplik - KF Tiranë 0:3
R (match retour) KF Tiranë - KF Veleçiku Koplik -:-
H (Match allé): 28.09.2022 15:00 R (match retour): 12.10.2022