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| 30.04.2022 | 11:00 | SC Freiburg | - | SSV Ulm 1846 | 4:0 (1:0) | |
| 11:00 | Kickers Offenbach | - | Bayern München | 3:2 (2:1) | ||
| 11:00 | SpVgg Unterhaching | - | 1899 Hoffenheim | 3:2 (0:2) | ||
| 13:00 | 1. FC Heidenheim 1846 | - | FC Augsburg | 0:1 (0:0) | ||
| 13:00 | SV Darmstadt 98 | - | 1. FC Saarbrücken | 0:2 (0:0) | ||
| 13:00 | Stuttgarter Kickers | - | VfB Stuttgart | 0:2 (0:1) | ||
| 13:00 | 1. FC Kaiserslautern | - | Eintracht Frankfurt | 0:4 (0:2) | ||
| 13:00 | FC Ingolstadt 04 | - | Hessen Kassel | 10:0 (4:0) | ||
| 13:00 | FC-Astoria Walldorf | - | 1. FC Nürnberg | 1:2 (1:1) | ||
| 13:00 | Karlsruher SC | - | SpVgg Greuther Fürth | 1:1 (1:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Augsburg | 20 | 14 | 4 | 2 | 56:31 | 25 | 46 |
| 2 |
|
1. FC Nürnberg | 20 | 15 | 1 | 4 | 45:27 | 18 | 46 |
| 3 |
|
Eintracht Frankfurt | 20 | 14 | 3 | 3 | 58:24 | 34 | 45 |
| 4 |
|
VfB Stuttgart | 20 | 14 | 2 | 4 | 55:16 | 39 | 44 |
| 5 |
|
1. FSV Mainz 05 | 20 | 11 | 3 | 6 | 58:39 | 19 | 36 |
| 6 |
|
1899 Hoffenheim | 20 | 10 | 5 | 5 | 64:36 | 28 | 35 |
| 7 |
|
SpVgg Unterhaching | 20 | 10 | 3 | 7 | 35:34 | 1 | 33 |
| 8 |
|
SC Freiburg | 20 | 9 | 4 | 7 | 43:34 | 9 | 31 |
| 9 |
|
Bayern München | 20 | 9 | 2 | 9 | 57:35 | 22 | 29 |
| 10 |
|
Karlsruher SC | 20 | 7 | 8 | 5 | 34:30 | 4 | 29 |
| 11 |
|
SV Darmstadt 98 | 20 | 8 | 5 | 7 | 28:32 | -4 | 29 |
| 12 |
|
1. FC Heidenheim 1846 | 20 | 8 | 4 | 8 | 35:30 | 5 | 28 |
| 13 |
|
FC Ingolstadt 04 | 20 | 7 | 4 | 9 | 44:40 | 4 | 25 |
| 14 |
|
FC-Astoria Walldorf | 20 | 6 | 7 | 7 | 39:35 | 4 | 25 |
| 15 |
|
1. FC Kaiserslautern | 20 | 8 | 1 | 11 | 39:54 | -15 | 25 |
| 16 |
|
Stuttgarter Kickers | 20 | 6 | 2 | 12 | 33:51 | -18 | 20 |
| 17 |
|
1. FC Saarbrücken | 20 | 6 | 0 | 14 | 20:41 | -21 | 18 |
| 18 |
|
SpVgg Greuther Fürth | 20 | 4 | 5 | 11 | 27:44 | -17 | 17 |
| 19 |
|
Kickers Offenbach | 20 | 5 | 2 | 13 | 24:48 | -24 | 17 |
| 20 |
|
SSV Ulm 1846 | 20 | 5 | 1 | 14 | 26:53 | -27 | 16 |
| 21 |
|
Hessen Kassel | 20 | 1 | 0 | 19 | 7:93 | -86 | 3 |
| Play-off | |
| Relégation |
